Inclusive Excellence Training Program in the Systems Biology of Cardiovascular Inflammation

项目摘要 一个由30名教师导师组成的优秀，多元化的团队已经在多个部门和学校共同努力 在明尼苏达大学（UMN），以形成一个新的博士学位。研究生培训计划，题为“包容性 心血管炎症系统生物学卓越培训计划。“这个项目填补了一个主要的 我们的研究机构通过强调高度临床相关的炎症问题， 心血管生物学、肥胖症、糖尿病和代谢，研究重点从基因到整个生物体。这 一项新的博士前培训计划提出了NHLBI的一项主要使命，即把重点放在生理系统上 培训的心血管和代谢炎症，这个新的计划将定位学员为不同的 在动态变化的未来劳动力中取得成功。这项新的培训计划也将填补一个大的 在UMN的博士前培训补助金中是无效的。教师导师来自几个不同的学院 和跨校园的部门，包括综合生物学和生理学（IBP），生物医学工程， 生物化学，细胞生物学和遗传学，微生物学和免疫学以及医学临床单位，包括 心脏病学、内分泌学、代谢学和儿科学。这一独特的重点和独特的努力， 该提案旨在培训下一代生物医学学者了解以下方面的原理和应用 整合与系统生物学从最纯粹的意义上说，我们的重点是提炼到人类的机械研究 physiology.不管是生理学、整合生物学、系统生物学、功能基因组学， 或者其他，这个培训补助金的前提是，从细胞到器官，到整体， 活的有机体，代表了生物医学科学新知识发现的领先浪潮，现在和未来， 未来几十年。该计划的毕业生将精通生物学的定量方法， 能够解剖活体动物体内复杂的机械路径。这一提议获得了相当大的收益。 通过与优秀的UMN网关研究生课程保持一致，以显着拓宽和深化 我们将从中挑选优秀的实习生候选人。此外，该提案还包括独特的 炎症生理学和计算系统生理学的定制学术课程 以最先进的计算生物学和信息学方法为特色。这些课程已 专门为这个新的培训项目而设计的在这里博士。学员将深入了解到最紧迫的 今天，代谢和心血管疾病的人类患者面临的问题。学员将获得更多 通过会议、研讨会、专题讨论会、务虚会、期刊俱乐部和 与项目教员（包括医生和科学家）举行小组会议。该计划旨在使我们的 毕业生追求独特的职业道路，从学术界到生物产业的系统和综合 生物学研究领域。

Project Summary An outstanding, diverse group of 30 faculty mentors has joined efforts across multiple departments and schools at the University of Minnesota (UMN) to form a new Ph.D. graduate training program entitled, "Inclusive Excellence Training Program in the Systems Biology of Cardiovascular Inflammation." This program fills a major void at our institution by focusing emphasis on the highly clinically relevant problem of inflammation in cardiovascular biology, obesity, diabetes and metabolism with study focus from gene to whole organism. This new predoctoral training proposal addresses a major mission of the NHLBI by focus on physiological systems training of cardiovascular and metabolic inflammation, and this new program will position trainees for diverse successful outcomes in the dynamically changing future workforce. This new training program will also fill a large void in the predoctoral training grant landscape at the UMN. Faculty mentors come from several different colleges and departments across campus, including Integrative Biology and Physiology (IBP), Biomedical Engineering, Biochemistry, Cell Biology and Genetics, Microbiology and Immunology and clinical units in Medicine, including Cardiology and Endocrinology and Metabolism, and Pediatrics. The unique focus and singular effort of this proposal is directed at training the next generation of biomedical scholars in the principles and application of Integrative and Systems Biology. In the purest sense, our focus is distilled into the mechanistic study of human physiology. By any name, whether it be physiology, integrative biology, systems biology, functional genomics, or other, this training grant’s premise is that understanding biological function from cells, to organs, to the whole living organism, represents the leading wave of new knowledge discovery in biomedical science now and in the decades to come. Graduates from this program will be well versed in quantitative approaches to biology and capable of dissecting complex mechanistic pathways in the living animal. This proposal gains considerable strength by aligning with outstanding UMN gateway graduate programs to markedly broaden and deepen the applicant pool from which we will select outstanding trainee candidates. Moreover, the proposal includes unique tailor-made academic courses in the Physiology of Inflammation and in Computational System Physiology featuring state-of-the-art computational biological and informatics approaches. These courses have been developed expressly for this new training program. Here Ph.D. trainees will gain insight into to the most urgent problems today in human patients with metabolic and cardiovascular medical disorders. Trainees will gain further experiential training in physiological research via conferences, seminars, symposia, retreats, journal clubs, and group meetings with program faculty, including physician-scientists. This program is designed to enable our graduates to pursue unique career pathways, spanning from academia to bio-industry in systems and integrative biology fields of research.