Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry

项目摘要 在美国印第安人中，实现卫生公平和消除差异的速度尤其缓慢 尽管缩小健康差距仍然是公共卫生机构的一个主要目标。 美国印第安人继续遭受不成比例的健康问题的困扰，包括 与营养相关的慢性疾病，如糖尿病和心脏病。因此，这项研究项目将 研究一种传统的本土食物--绞股蓝是如何影响表观遗传学和 50名大平原印度参与者的代谢健康与弹性标记物的关系。绞股蓝是一种 本地传统食品和药物，单独使用或在pemmican的混合物中使用(水牛、脂肪的混合物 在西方接触之前，在美国和加拿大的某些地区很常见。由于 除了炎症标记物外，绞股蓝对人体的血脂和血糖测定也有积极作用 以前在非土著环境中的研究表明，它值得在这一群体中进一步探索 有着截然不同的基因和新陈代谢特征。另外，与美国印第安人的研究过程 社区的重要意义在于，它可以为社区参与导向方面的最佳做法提供信息， 未来研究环境中的方法和模型。 我们的具体目标是探索由传统食品消费所介导的基因表达变化。 为了研究美国大平原印第安人的土生土长的绞股蓝和新陈代谢终点之间的关系， 表观遗传学、不良童年经历和精神健康 美国大平原印第安人的一种野莓。我们的长期目标是增加关于关系的知识库 美国印第安人传统食物消费、基因表达变化与代谢标志物的关系 与创伤和复原力有关。 我们的研究是横断面和纵向研究设计的混合体。基准表观遗传学、代谢性和 心理健康数据将从研究参与者那里收集，用于横断面分析，并带有表观遗传学 筛查后特别重复餐后饮用窒息莓汁，以评估其效果从 基线。表观遗传、新陈代谢和心理健康数据的收集过程将在6点后重复 比较收集变量与前一次的几周时间内每天的窒息浆果果汁消费量 收藏。

Project Abstract Achieving health equity and eliminating disparities has been especially slow in American Indian populations even though reducing health disparities continues to be a major goal of public health institutions. American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease. This research project will therefore investigate how a traditional Indigenous food called chokeberry (Aronia melanocarpa) impacts epigenetic and metabolic health in relation to resiliency markers in fifty Great Plains Indian participants. Chokeberry is an Indigenous traditional food and medicine used on its own or in mixtures of pemmican (a mixture of buffalo, fat and chokeberry) common before Western contact in certain areas of the United States and Canada. Due to chokeberry’s positive effects on human lipid and glucose measures, in addition to inflammation markers demonstrated in prior studies in non-Indigenous settings, it is worthy of further exploration in this population with very different gene and metabolic profiles. Also, the process of research with American Indian communities is significant in that it can inform best practices in community engagement orientations, approaches, and models in future research settings. Our specific aims are to explore gene expression changes that are mediated by the consumption of traditional Indigenous chokeberry in Great Plains Indians and to examine the associations between metabolic end points, epigenetics, adverse childhood experiences, and mental health with and without the consumption of chokeberry in Great Plains Indians. Our long-term aim is to increase the knowledge base on the relationships between American Indian traditional food consumption, gene expression changes and metabolic markers in relation to trauma and resilience. Our study is a mix of a cross-sectional and longitudinal study design. Baseline epigenetic, metabolic and mental health data will be collected from study participants for cross sectional analysis, with the epigenetic screen specifically repeated after the post prandial consumption of chokeberry juice to assess its effects from baseline. The epigenetic, metabolic and mental health data collection process will then be repeated after 6 weeks of the daily consumption of chokeberry juice to compare the collection variables to the previous time collections.