Historical trauma and resilience as a biological state and its association with the effects of the traditional Indigenous food chokeberry

作为一种生物状态的历史创伤和复原力及其与传统土著食物野莓的影响的关联

• 批准号: 10091062
• 负责人: Nicole Redvers
• 金额: $ 22.56万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10091062
• 关键词: Adult; Affect; American; American Indians; Anxiety; Area; Attenuated; Biological; Biological Markers; Black Chokecherry Tree; Blood Pressure; Buffaloes; Canada; Centers of Research Excellence; Chronic Disease; Collection; Communities; Complex; Consumption; Cross-Sectional Studies; Cultural Backgrounds; DNA; Data Collection; Development; Diabetes Mellitus; Dietary Intervention; Environment; Environmental Risk Factor; Epigenetic Process; Exposure to; Fatty acid glycerol esters; Food; Functional disorder; Gene Expression; Gene Mutation; Generalized Anxiety Disorder; Genes; Genetic; Glucose; Goals; Great Plains; Health; Heart Diseases; Household; Human; IL6 gene; Indigenous; Individual; Inflammatory; Institution; Interleukin-6; Juice; Lipids; Longitudinal Studies; Measures; Mediating; Medicine; Mental Depression; Mental Health; Metabolic; Metabolic Marker; Metabolism; Methylation; Modeling; Nutritional; Outcome; Outcome Measure; Participant; Patients; Phase; Physiological; Population; Post-Traumatic Stress Disorders; Prevalence; Prevention strategy; Process; Public Health; Questionnaires; Research; Research Design; Research Project Grants; Resources; Serum; Smoking; Testing; Time; Trauma; United States; abuse neglect; adverse childhood events; alcohol misuse; blood lipid; community engagement; conditioning; dietary; disparity elimination; epigenetic marker; food consumption; health data; health disparity; health equity; imprint; improved; inflammatory marker; innovation; interest; knowledge base; metabolic profile; nutrition; pediatric trauma; resilience; secondary outcome; social; tool; western diet

Project Abstract Achieving health equity and eliminating disparities has been especially slow in American Indian populations even though reducing health disparities continues to be a major goal of public health institutions. American Indian populations continue to suffer disproportionately from health problems including such nutrition-related chronic diseases as diabetes and heart disease. This research project will therefore investigate how a traditional Indigenous food called chokeberry (Aronia melanocarpa) impacts epigenetic and metabolic health in relation to resiliency markers in fifty Great Plains Indian participants. Chokeberry is an Indigenous traditional food and medicine used on its own or in mixtures of pemmican (a mixture of buffalo, fat and chokeberry) common before Western contact in certain areas of the United States and Canada. Due to chokeberry’s positive effects on human lipid and glucose measures, in addition to inflammation markers demonstrated in prior studies in non-Indigenous settings, it is worthy of further exploration in this population with very different gene and metabolic profiles. Also, the process of research with American Indian communities is significant in that it can inform best practices in community engagement orientations, approaches, and models in future research settings. Our specific aims are to explore gene expression changes that are mediated by the consumption of traditional Indigenous chokeberry in Great Plains Indians and to examine the associations between metabolic end points, epigenetics, adverse childhood experiences, and mental health with and without the consumption of chokeberry in Great Plains Indians. Our long-term aim is to increase the knowledge base on the relationships between American Indian traditional food consumption, gene expression changes and metabolic markers in relation to trauma and resilience. Our study is a mix of a cross-sectional and longitudinal study design. Baseline epigenetic, metabolic and mental health data will be collected from study participants for cross sectional analysis, with the epigenetic screen specifically repeated after the post prandial consumption of chokeberry juice to assess its effects from baseline. The epigenetic, metabolic and mental health data collection process will then be repeated after 6 weeks of the daily consumption of chokeberry juice to compare the collection variables to the previous time collections.

项目摘要