Rural Drug Addiction Research Center

项目摘要 美国非法药物使用的性质和挑战继续迅速变化， 无数的社会经济和地方力量虽然吸毒成瘾影响到该国的每一个地区， 有关吸毒的信息来自大城市地区。关于农村成瘾及其危害的新数据证明了 更多的关注。记录药物使用，成瘾，并在农村各州过量的比率，加上缺乏 治疗设施，表明健康状况迅速恶化。虽然健康科学已经取得了相当大的进展， 在了解吸毒病因学和揭示吸毒与其许多方面的 尽管这一充满希望的科学消息与相关危害有关，但尚未转化为更好的农村健康成果。的目标 本申请旨在创建一个可持续发展的、国家认可的中心--农村药物添加研究中心 中心（RDAR）-致力于了解农村吸毒成瘾及其相关问题的原因和影响 挑战和危害。鉴于成瘾的多因素性质，这项研究必须跨越一个连续体展开 从突触的微观层面到更大的社会背景。因此，RDAR将绘制 内布拉斯加大学的高级研究人员和现有资源，以指导早期的职业科学家 在开展从多个角度应对农村毒品使用挑战的前沿研究时（即，从 与社会的联系）。例如，最初的研究项目将集中在成瘾的神经科学，认知， 长期吸毒的影响、农村吸毒与暴力暴露之间的关系以及 药物相关疾病流行病学结构模拟。为了支持这些项目，RDAR将找到 纵向网络核心（LNC），围绕尖端队列跟踪和保留而构建的研究核心 由RDAR高级研究人员开发的软件，为RDAR项目提供纵向队列研究能力。 LNC将招募和保留一批农村吸毒者，RDAR项目将定期收集这些吸毒者的数据。的 中心将提供专门的指导、专业发展和中心资源， 从事农村药物成瘾研究的调查人员成为独立资助的研究人员（目标1） 同时为农村非法药物使用及其 伤害（目标2）。这将为长期中心基础设施（目标3）奠定基础， 研究人员领导努力解决农村吸毒成瘾带来的具体挑战， 对这些情况进行适当干预。RDAR将结合联合收割机的资源， 研究型大学（内布拉斯加大学林肯分校）和大学医学中心（内布拉斯加大学林肯分校） 内布拉斯加州医学中心），以创造一个可持续的研究环境，利用现有的合作 与当地从业者和国家政策和服务组织。最后，以试点形式提供的机构支助 在对RDAR重要的研究领域，项目资金和新的教师招聘将有助于确保长期的 中心的可持续性。

PROJECT ABSTRACT The nature and challenge of illicit drug use in the United States continues to change rapidly, evolving in reaction to myriad social, economic, and local forces. While drug addiction affects every region of the country, most information about drug use comes from large urban areas. Emerging data on rural addiction and its harms justify greater attention. Record drug use, addiction, and overdose rates in rural states, coupled with a dearth of treatment facilities, point to a rapidly worsening health situation. While health sciences have made considerable progress in understanding the etiology of drug use and uncovering the link between drug use and its many associated harms, this promising scientific news has yet to translate to better rural health outcomes. The goal of this application is to create a sustainable, nationally recognized Center—the Rural Drug Addition Research Center (RDAR)—dedicated to understanding the causes and impacts of rural drug addiction and its related challenges and harms. Given the multifactorial nature of addiction, this research must unfold across a continuum of domains, ranging from the microscopic level of the synapse to larger social contexts. As such, RDAR will draw on senior investigators and existing resources from the University of Nebraska to mentor early career scientists in conducting cutting-edge research that addresses rural drug use challenges from multiple angles (i.e., from synapse to society). For example, initial research projects will focus on the neuroscience of addiction, cognitive implications of chronic drug use, the relationship between rural drug use and violence exposure, and spatial and structural simulation of drug-related disease epidemiology. To support these projects, RDAR will found the Longitudinal Networks Core (LNC), a research core built around cutting-edge cohort tracking and retention software developed by RDAR senior investigators to offer longitudinal cohort study capacity to RDAR projects. LNC will recruit and retain a cohort of rural drug users from which RDAR projects will regularly collect data. The Center will provide dedicated mentoring, professional development, and Center resources to enable early stage investigators engaged in rural drug addiction research to become independently funded researchers (Aim 1) while creating a sustainable environment for interdisciplinary research excellence on rural illicit drug use and its harms (Aim 2). This will lay the groundwork for long-term Center infrastructure (Aim 3) that allows RDAR researchers to lead efforts to address specific challenges raised by drug addiction in rural settings and develop appropriate interventions for those settings. RDAR will combine the resources of a nationally recognized research university (University of Nebraska-Lincoln) and a university-based medical center (University of Nebraska Medical Center) to create a sustainable research environment, capitalizing on existing collaborations with local practitioners and state policy and service organizations. Lastly, institutional support in the form of pilot project funding and new faculty hires in research areas important to RDAR will help ensure the long-term sustainability of the Center.