Interoceptive conditioning with nicotine: Changes in abuse liability
尼古丁的内感受调节:滥用倾向的变化
基本信息
- 批准号:10406337
- 负责人:
- 金额:$ 35.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-15 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAlcohol consumptionAlcoholsAnimal ModelAreaAttentionAwarenessBehaviorBehavioralBiologicalChronicCigaretteDesire for foodDevelopmentDiseaseDoseDrug abuseEthanolExtinction (Psychology)FemaleFoodGoalsHealthHeart DiseasesHeart RateIndividualIntakeInteroceptionIntravenousLearningLinkLiteratureMalignant NeoplasmsMeasuresMethodsNicotineNicotine DependencePharmaceutical PreparationsPharmacologyPre-Clinical ModelProcessProtocols documentationPsychopathologyRattusRecording of previous eventsRelapseResearchResearch PersonnelRiskRoleScienceScientific Advances and AccomplishmentsSelf AdministrationSex DifferencesSex FactorsSmokerSmokingSocietiesStimulusStressSucroseTestingTimeTobaccoTobacco useWomanWorkabuse liabilityaddictionbaseconditioningdesigndrug seeking behavioreconomic costenhancing factorenvironmental tobacco smokeimproved outcomeinnovationmalemennegative affectnicotine replacementnicotine usenovelpeerpre-clinicalprogramsreinforcerresponsesexsmoking cessationsynergismtheories
项目摘要
PROJECT ABSTRACT
Nicotine is the primary addictive constituent in tobacco. For an individual, chronic tobacco use is associated
with a significant increase in heart disease and many forms of cancer; even the health of non-tobacco users is
negatively affected by second-hand smoke. There are some important sex differences in this addiction and its
health consequences. Women on average take less time than men to become nicotine dependent, make fewer
attempts to quit smoking, abstain for less time, relapse at higher rates, and benefit less from nicotine
replacement therapy. Clearly, enormous gains to the individual and society would come from a better
understanding of factors that contribute to nicotine dependence. Environmental stimuli associated with drugs
such as nicotine can be powerful modulators of drug-seeking behavior. Another important factor to the
development and tenacity of nicotine dependence is the pharmacological effects of nicotine serving as an
interoceptive (internal) stimulus entering into a conditioned association with other reinforcers/unconditioned
stimuli [USs (peer acceptance, alcohol, work breaks, stress relief)]. Consequently, over time, a smoker has an
opportunity to develop a rich appetitive conditioning history with the stimulus effects of nicotine. This acquired
reinforcing value likely contributes to the tenacity of the nicotine addiction. Using a newly developed
preclinical animal model that innovatively merges interoceptive conditioning with nicotine self-administration,
the present application will rigorously test the hypothesis that following an appetitive interoceptive
conditioning history with nicotine, the nicotine stimulus will acquire conditioned reinforcing value that
exacerbates the persistence of nicotine-taking behavior. To this end, the Specific Aims will examine how such
enhancement of drug intake varies with the salience (dose) of the nicotine stimulus (Aim 1), assess the synergy
between nicotine and ethanol by using ethanol or sucrose-ethanol solution as the US (Aim 2), and implement
an innovative extinction protocol designed to weaken the acquired conditioned reinforcing value of nicotine to
a greater extent than just simple non-reinforcement of the target stimulus (Aim 3) in female and male rats.
项目摘要
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Female rats display higher methamphetamine-primed reinstatement and c-Fos immunoreactivity than male rats.
- DOI:10.1016/j.pbb.2020.173089
- 发表时间:2021-03
- 期刊:
- 影响因子:3.6
- 作者:Pittenger, Steven T.;Chou, Shinnyi;Murawski, Nathen J.;Barrett, Scott T.;Loh, Olivia;Duque, Juan F.;Li, Ming;Bevins, Rick A.
- 通讯作者:Bevins, Rick A.
Reward-enhancing effects of d-amphetamine and its interactions with nicotine were greater in female rats and persisted across schedules of reinforcement.
- DOI:10.1097/fbp.0000000000000637
- 发表时间:2021-08-01
- 期刊:
- 影响因子:1.6
- 作者:McNealy KR;Ramsay ME;Barrett ST;Bevins RA
- 通讯作者:Bevins RA
The importance of acquisition learning on nicotine and varenicline drug substitution in a drug-discriminated goal-tracking task.
- DOI:10.1016/j.pbb.2020.173045
- 发表时间:2020-12
- 期刊:
- 影响因子:0
- 作者:Thompson BM;Barrett ST;Huynh YW;Kwan DA;Murray JE;Bevins RA
- 通讯作者:Bevins RA
Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.
- DOI:10.1016/j.neuropharm.2021.108845
- 发表时间:2022-01-01
- 期刊:
- 影响因子:4.7
- 作者:McNealy KR;Houser SD;Barrett ST;Bevins RA
- 通讯作者:Bevins RA
The Sugars in Alcohol Cocktails Matter.
- DOI:10.1021/acschemneuro.1c00526
- 发表时间:2021-09-15
- 期刊:
- 影响因子:5
- 作者:Wakabayashi KT;Greeman EA;Barrett ST;Bevins RA
- 通讯作者:Bevins RA
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Rick A Bevins其他文献
Rick A Bevins的其他文献
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{{ truncateString('Rick A Bevins', 18)}}的其他基金
Understanding and mitigating exacerbated nicotine use resulting from Pavlovianinteroceptive conditioning
了解和缓解巴甫洛夫内感受调节导致的尼古丁使用加剧
- 批准号:
10736191 - 财政年份:2023
- 资助金额:
$ 35.72万 - 项目类别:
National IDeA Symposium of Biomedical Research Excellence - NISBRE
全国 IDeA 生物医学研究卓越研讨会 - NISBRE
- 批准号:
10597964 - 财政年份:2022
- 资助金额:
$ 35.72万 - 项目类别:
Interoceptive conditioning with nicotine: Changes in abuse liability
尼古丁的内感受调节:滥用倾向的变化
- 批准号:
10163151 - 财政年份:2018
- 资助金额:
$ 35.72万 - 项目类别:
Extracellular vesicles, meth relapse and sex differences
细胞外囊泡、冰毒复发和性别差异
- 批准号:
10200728 - 财政年份:2018
- 资助金额:
$ 35.72万 - 项目类别:
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