Immunology Core

这一核心组件将利用我们建立的疫苗评估渠道，其中包括我们的 创新的高通量方法有助于我们的抗原工程工作，同时允许 抗血清对给定蛋白质的所有已知抗原变体的反应性，以及我们的 人性化的基于老鼠的感染模型，使我们能够测试疫苗在 淋球菌无症状定植和疾病。这个核心产生的结果是疫苗的核心 项目1和项目2正在进行设计和配方工作，并将用于为疫苗提供信息 正在项目3中执行影响建模。

This Core component will take advantage of our established vaccine evaluation pipeline, which includes our innovative high throughput approaches facilitate our antigen engineering efforts by simultaneously allowing the reactivity of antiserum to be measured against all known antigenic variants of a given protein, and our humanized mouse-based infection models, which allow us to test the protective efficacy of vaccines during gonococcal asymptomatic colonization and disease. The results generated by this Core are central to vaccine design and formulation efforts being undertaken in Projects 1 and 2, and will be used to inform the vaccine impact modeling being performed in Project 3.