AGING, BRAIN IMAGING, AND COGNITION

描述(调查者摘要)：建议的研究桥梁 流行病学和调查研究的优势与结构研究的优势 神经成像所有认知评估，这是更典型的 在没有密切关注正常人群的情况下进行 志愿者受试者被招募。建议的研究样本将包括 在242名年龄在20岁以上的成年人中，以概率抽样的方式选择 11个年龄层各有11名男性和11名女性，其中110人 年龄在65岁或以上的受试者，以及年龄在80岁及以上的子场。 选择概率将确保样本的种族分布 与非洲裔美国人的比例代表制相对应 根据美国人口普查，美国成年人口中的白人 对1995年预测，大约50%的受试者 年龄阶层将是高中毕业生。 这项横断面调查将调查疑似与年龄有关的 神经解剖学、认知功能和表现的差异 (例如，日常生活活动)。抽样后，受试者将 招聘以办公室为基础测量定量体积 神经解剖学，使用从3D体积再现获得的可靠测量 核磁共振扫描。与此同时，认知功能的详细测量， 目前的身体健康，健康史和血脂都将是 评估过了。拟议研究的具体目标是：评估交叉- 全身性和局部性脑测量的分段年龄差异 从磁共振成像，认知表现的多个领域，和功能 限制或残疾。这将产生关于特定差异的数据 以及一套全面的参考值 跨年龄层的大脑解剖、认知和功能。我们设想 这项横断面调查工作是今后工作的基础 与年龄相关的脑解剖变化的前瞻性纵向研究 与功能受损有关。我们将评估具体的相关 磁共振成像和功能测量集合之间的相互关系， 研究这些相关性在不同年龄层之间的变化。为 例如，大脑结构和功能状态的参数将为 根据它们与可疑来源的联系进行审查 与病史、人口统计背景和当前情况的差异 医疗状况。图像、参考值和其他产品 在拟议的项目中收集的研究将在网上提供 通过互联网用于其他研究中心；在核磁共振的情况下 图像，作为NIH脑图项目的一部分。

DESCRIPTION (Investigator's Abstract): The proposed research bridges strength of epidemiology and survey research with those of structural neuro-imaging all cognitive assessment, which are more typically conducted without close attention to the population from which normal volunteer subjects are recruited. The proposed study sample will consist of 242 adults ages 20+, selected with probability sampling so that there will be 11 men and 11 women in each of 11 age strata, with 110 of the subjects aged 65 years or older, and subfields aged 80 years and older. Selection probabilities will ensure that the samples racial distribution corresponds to the proportional representation of African-Americans and Caucasians in the U.S. adult Population, based on the U.S. census projection for 1995, and that approximately 50% of subjects with each age stratum will be high school graduates. This cross-sectional survey will investigate suspected age-related differences in neuroanatomy, cognitive functioning and performance (e.g., activities of daily living). After sampling, subjects will be recruited for office-based measurements of quantitative volumetric neuro-anatomy, using reliable measures obtained from 3-D volume-rendered MRl scans. At the same time, detailed measures of cognitive functioning, current physical health, health history and plasma lipids will all be assessed. The specific aims of the proposed study are: To assess cross- sectional age differences in generalized and regional brain measures from MRI, multiple domains of cognitive performance, and functional limitations or disability. This will yield data on specific differences across age strata as well as a set of comprehensive reference values for brain anatomy, cognition, and function across, age strata. We envisage this cross-sectional survey work serving as the basis for future prospective longitudinal studies of age-related brain anatomic changes related to impaired functioning. We will assess specific correlative inter-relationships among MRI and the sets of functional measures, investigating variation in these correlations across age strata. For example, parameters of brain structure and functional status will be examined in terms of their association with suspected sources of variation from medical history, demographic background, and current medical status. Images, reference values and other products of this research gathered in the proPosed project will be made available on-line via internet for use in other research centers; in the case of MRI images, as part of NIH's BRAIN MAP project.