Neuroscience of Marijuana Impaired Driving
大麻驾驶障碍的神经科学
基本信息
- 批准号:8990677
- 负责人:
- 金额:$ 67.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2020-05-31
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAcuteAddressAffectAlcoholsAnatomyAnteriorAutomobile DrivingAwarenessBehaviorBehavioralBehavioral ResearchBiologicalBloodBrainBreathingCannabidiolCannabinoidsCannabinolCannabisCause of DeathChronicCognitionCognitiveCognitive deficitsDataDependenceDoseDouble-Blind MethodDriving While IntoxicatedFunctional Magnetic Resonance ImagingFutureGoalsHourImpaired cognitionImpairmentIntoxicationLaboratoriesLaw EnforcementLegalLinkLiquid substanceMarijuanaMarijuana SmokingMeasuresMediatingMedicalMotor VehiclesNeuropsychological TestsNeurosciencesOralParietalParticipantPatternPerformancePersonsPharmaceutical PreparationsPlacebo ControlPlacebosPoliciesProceduresPublic HealthRandomizedReportingResearchRiskSafetySalivaSalivarySamplingSeveritiesSocial ClassStagingStrategic PlanningTestingTetrahydrocannabinolTimeTraffic accidentsUnited StatesVaporizerVehicle crashVisitVisualalcohol and other drugautomobile accidentbasebehavior changecognitive taskcognitive testingdesigndriving behaviorexperiencefield sobriety testsimpaired driving performanceinjuredmarijuana usemarijuana userneural circuitnoveloperationpublic health relevancerelating to nervous systemresponsesalivary assayscreeningskillssobrietysocialtraffickingvirtual
项目摘要
DESCRIPTION (provided by applicant): Driving while intoxicated on cannabis is a major and growing public health problem. Driving safety is an important issue in the United States as more than 3 million persons are reported injured and >40,000 die annually in motor vehicle crashes. Traffic accidents are the greatest single cause of death in 5-32 year-olds; many are due to intoxicated drivers. Cannabis (CNB) is a commonly abused drug whose use cuts across social class, is linked to cognitive impairment, is a major contributor to intoxication-related accidents either alone or with alcohol. However, CNB intoxication is little studied in relation to driving compared to alcohol. Not only does the current NHTSA Strategic Plan for Behavioral Research prioritize understanding how drugs other than alcohol contribute to traffic crashes, it has recentl become more pressing to understand the effects of CNB because of increasing rates of legalized medical and/or recreational use, that will likely result in more CNB intoxicated drivers.
Social and legal policy will be unable to effectively address the many concerns about driving safety raised by more frequent and widespread use of CNB without new research to better determine the parameters within which CNB use does, or does not, increase automobile accident risk. Our purpose is to better describe specific, driving-related cognitive impairments caused by acute CNB intoxication, their persistence over time, underlying functional brain anatomy, and relationship to performance on a state-of the art validated simulated driving task in which we have prior experience. In a randomized, counterbalanced, double-blinded fashion, we will administer two CNB doses and placebo of smoked cannabis (paced inhalation using a vaporizer) to 48 regular and 48 occasional cannabis users on 3 separate occasions. Following CNB dosing we will assess cognitive and driving impairment longitudinally for several hours using a combination of fMRI and neuropsychological tests, to clarify relationships between subjective and objective measures of intoxication and of impairment, that include expert assessment of THC and its metabolite levels in blood and saliva.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GODFREY D PEARLSON其他文献
GODFREY D PEARLSON的其他文献
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{{ truncateString('GODFREY D PEARLSON', 18)}}的其他基金
3/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)
3/5 生物标志物/生物型,早期精神病课程和专业服务 (BICEPS)
- 批准号:
10683286 - 财政年份:2022
- 资助金额:
$ 67.6万 - 项目类别:
3/5 Selective Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (CLOZAPINE)
B-SNIP Biotype-1 (CLOZAPINE) 中氯氮平的选择性抗精神病反应为 3/5
- 批准号:
10396432 - 财政年份:2021
- 资助金额:
$ 67.6万 - 项目类别:
3/5 Selective Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (CLOZAPINE)
B-SNIP Biotype-1 (CLOZAPINE) 中氯氮平的选择性抗精神病反应为 3/5
- 批准号:
10613491 - 财政年份:2021
- 资助金额:
$ 67.6万 - 项目类别:
Neuroimaging predictors of bariatric surgical outcomes
减肥手术结果的神经影像预测因素
- 批准号:
10180948 - 财政年份:2018
- 资助金额:
$ 67.6万 - 项目类别:
Neuroimaging predictors of bariatric surgical outcomes
减肥手术结果的神经影像预测因素
- 批准号:
10430196 - 财政年份:2018
- 资助金额:
$ 67.6万 - 项目类别:
Neuroimaging predictors of bariatric surgical outcomes
减肥手术结果的神经影像预测因素
- 批准号:
9981729 - 财政年份:2018
- 资助金额:
$ 67.6万 - 项目类别:
3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)
3/4-精神病
- 批准号:
8504331 - 财政年份:2013
- 资助金额:
$ 67.6万 - 项目类别:
3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)
3/4-精神病
- 批准号:
8917630 - 财政年份:2013
- 资助金额:
$ 67.6万 - 项目类别:
3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)
3/4-精神病
- 批准号:
8706966 - 财政年份:2013
- 资助金额:
$ 67.6万 - 项目类别:
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