Natural product derived parasiticides for the protection of food animals

每年，全球有价值的牲畜因无脊椎寄生虫而死亡，包括内寄生虫（线虫或蠕虫）和外寄生虫（苍蝇、蜱虫、螨虫和海虱），总损失达340亿英镑。尽管全球农民在杀寄生虫剂（治疗寄生虫感染的化合物）上花费了45亿英镑。随着新的寄生虫的出现和现有寄生虫进化出耐药性，不断需要新的产品。更糟糕的是，由于发现新化合物和获得监管部门批准的难度越来越大，进入市场的新药物越来越少。在这个项目中，acidophill与Isomerase合作，旨在将合成生物学和化学结合起来，产生新的天然产物衍生的杀寄生虫剂，以解决食品动物健康领域对新型和具有成本效益的杀寄生虫剂的迫切需求

Every year the loss of valuable livestock to invertebrate parasites, both endoparasites (nematodes or helminths) and ectoparasites (flies, ticks, mites and sea lice) totals >£34 billion globally. This is despite the fact that farmers spend ~£4.5 billion globally on parasiticides (compounds to treat parasitic infections). New products are continually needed as new parasites emerge and existing parasites evolve resistance. To compound this issue fewer novel agents are entering the market due to the increasing difficulties of discovering novel compounds and getting regulatory approval. In this project, Acidophil collaborating with Isomerase aim to combine synthetic biology and chemistry to generate novel natural product derived parasiticides to address the pressing unmet need in food animal health for new and cost effective parasiticides