The molecular basis of T cell receptor cross-reactivity between MHC and MR1

该项目旨在研究新发现的免疫细胞（称为“MR1T”细胞）如何在体内发挥作用。初步证据表明，MR1T细胞可以杀死应激细胞。该项目预计将产生新的知识，精确描述MR1T细胞如何靶向和杀死应激细胞。该项目的预期成果包括完善研究技术和模型，促进机构间合作，并进一步发展我们关于MR 1 T细胞功能的理论。该项目将带来显著的效益，例如在高影响力期刊上发表研究文章，并产生该领域研究人员所寻求的实验工具。

This project aims to investigate how newly discovered immune cells, known as 'MR1T' cells, function in the body. Preliminary evidence shows that MR1T cells can kill stressed cells. This project expects to generate new knowledge describing precisely how MR1T cells target and kill stressed cells. Expected outcomes of this project include to refine research techniques and models, foster interinstitutional collaborations, and further develop our theory on MR1T cell function. This project should provide significant benefits, such as publication of research articles in high impact journals and generation of experimental tools sought after by researchers in the field.