DEVELOPMENT OF HIGH PERFORMANCE SPECT IMAGING

ECT（发射计算机断层扫描）最独特和最有前途的方面 技术，包括PET（正电子CT）和SPECT（单光子 ECT），是他们的潜力，量化区域细胞功能，通过非- 三维示踪剂分布的侵入性成像。 这种潜力已经 在PET成像中已经部分实现，但它的开发程度要低得多 对于更受欢迎和更广泛使用的SPECT，因为 典型的低效率、差的空间分辨率，以及更严重的 衰减效应 虽然固有的困难更大，但我们 相信SPECT可以用于定量成像， 临床上有意义的水平，通过进一步优化技术方面的 成像过程。 在目前的项目中，我们成功地开发了第一个 原型脑SPECT系统（McI），并正在完成一个更实用的 临床脑系统（McII）的性能得到改善。 直接 我们现有项目的扩展，这个拟议项目是应用我们的 概念和专业知识进一步沿着同一路线开发身体SPECT 系统 该项目的主旨将保持不变： 通过集成的硬件和软件优化SPECT技术 approach. 我们仍将重点放在优化前端 硬件，以确保采集数据的质量。 先进的加工 将开发最佳提取诊断信息的技术。 本项目的主题是开发一种新的高性能SPECT 系统（McB）用于心脏成像，同时保持其他 身体成像应用。 一种实用衰减器的研制 校正技术至关重要，这是提高 新成像系统的量化能力。 我们最近 开发了一个新的概念，这是实施作为一个实际的传输 成像（AsFTCT）用于导出μ图，这是 适当的衰减校正。我们将把新技术整合到 建议的McB系统的设计。 McB系统的设计和建设将改善我国城市的交通状况， 身体和心脏SPECT成像技术。 高性能 （灵敏度和/或高空间分辨率）和定量 所提出的系统的能力可以提高临床实用性 心脏成像。 同样重要的是，拟议的衰减 所开发的校正技术是通用的并且适用于其它SPECT 系统. 该研究项目将广泛促进 SPECT成像朝着定量的长期目标发展 功能成像

The most unique and promising aspect of ECT (emission computed tomography) techniques, which include both PET (positron CT) and SPECT (single photon ECT), is their potential to quantify regional cell functions through non- invasive imaging of 3D tracer distribution. This potential has already been partially realized in PET imaging, but it is much less well developed for the more popular and widely accessible SPECT because of the characteristic low efficiency, poor spatial resolution, and more severe attenuation effect. Although the inherent difficulty is greater, we are convinced that SPECT can be developed for quantitative imaging to a clinically meaningful level by further optimizing technical aspects of the imaging process. During the current project, we have successfully developed the first prototype brain SPECT system (McI) and are finishing a more practical clinical brain system (McII) with improved performance. As a direct extension of our existing project, this proposed project is to apply our concepts and expertise further along the same line to develop a body SPECT system. The general thrust of the project will remain unchanged: to optimize SPECT techniques through an integrated hardware and software approach. We will still place major emphasis on optimizing the front-end hardware to assure the quality of acquired data. Advanced processing techniques will be developed to optimally extract diagnostic information. The theme of this proposal is to develop a new high-performance SPECT system (McB) for cardiac imaging, while maintaining the potential for other body imaging applications. The development of a practical attenuation correction technique is crucial; this is a key for improving the quantification capability of the new imaging system. We have recently developed a novel concept which is implemented as a practical transmission imaging (AsFTCT) for deriving mu-maps, which are the pre-requisite for proper attenuation correction. We will integrated the new technique into the design of the proposed McB system. The design and construction of the McB system will improve the state-of- the-art of body and cardiac SPECT imaging. The high performance (sensitivity and/or high spatial resolution) and the quantification capability of the proposed system could lead to improved clinical utility of cardiac imaging. Equally significant, the proposed attenuation correction techniques developed are generic and applicable to other SPECT systems. This research project should contribute broadly to the advancement of SPECT imaging toward the long-term goal of quantitative functional imaging.