DEVELOPMENT OF HIGH PERFORMANCE SPECT IMAGING

ECT(发射计算机断层扫描)最独特和最有前途的方面 技术，包括正电子CT(正电子CT)和SPECT(单光子) ECT)，是它们通过非ECT来量化区域细胞功能的潜力 三维示踪剂分布的侵入性成像。这种潜力已经 已经在PET成像中部分实现了，但它还不太发达 对于更受欢迎和更广泛访问的SPECT，因为 具有效率低、空间分辨率差、严重程度高等特点 衰减效果。尽管内在的困难更大，但我们正在 相信SPECT可以被开发用于定量成像到 临床有意义的水平通过进一步优化技术方面的 成像过程。 在目前的项目中，我们已经成功地开发了第一个 脑SPECT原型系统(MCI)和正在完成的更实用的 性能改进的临床脑系统(MCII)。作为一种直接 延长我们现有的项目，这个拟议的项目是为了应用我们的 沿着同一路线进一步发展身体SPECT的概念和专业知识 系统。该项目的总体主旨将保持不变： 通过集成的硬件和软件优化SPECT技术 接近。我们仍将把重点放在优化前端 硬件，以确保采集数据的质量。高级处理 将开发以最佳方式提取诊断信息的技术。 这项建议的主题是开发一种新的高性能SPECT 用于心脏成像的系统(MCB)，同时保持对其他 身体成像应用。一种实用衰减器的研制 纠正技术是至关重要的；这是提高 新成像系统的量化能力。我们最近做了 开发了一种新的概念，作为一种实际的变速箱来实施 用于导出MU图的成像(AsFTCT)，这是 适当的衰减校正。我们将把这项新技术集成到 提出的母牛断路器系统的设计。 MCB系统的设计和建设将改善我国铁路建设的现状。 身体和心脏SPECT成像的艺术。高性能 (敏感度和/或高空间分辨率)和量化 建议的系统的能力可以导致临床实用性的提高 心脏成像技术。同样重要的是，提议的衰减 所开发的校正技术是通用的，并适用于其他SPECT 系统。这项研究项目应该对 SPECT显像向量化远期目标的进展 功能成像。

The most unique and promising aspect of ECT (emission computed tomography) techniques, which include both PET (positron CT) and SPECT (single photon ECT), is their potential to quantify regional cell functions through non- invasive imaging of 3D tracer distribution. This potential has already been partially realized in PET imaging, but it is much less well developed for the more popular and widely accessible SPECT because of the characteristic low efficiency, poor spatial resolution, and more severe attenuation effect. Although the inherent difficulty is greater, we are convinced that SPECT can be developed for quantitative imaging to a clinically meaningful level by further optimizing technical aspects of the imaging process. During the current project, we have successfully developed the first prototype brain SPECT system (McI) and are finishing a more practical clinical brain system (McII) with improved performance. As a direct extension of our existing project, this proposed project is to apply our concepts and expertise further along the same line to develop a body SPECT system. The general thrust of the project will remain unchanged: to optimize SPECT techniques through an integrated hardware and software approach. We will still place major emphasis on optimizing the front-end hardware to assure the quality of acquired data. Advanced processing techniques will be developed to optimally extract diagnostic information. The theme of this proposal is to develop a new high-performance SPECT system (McB) for cardiac imaging, while maintaining the potential for other body imaging applications. The development of a practical attenuation correction technique is crucial; this is a key for improving the quantification capability of the new imaging system. We have recently developed a novel concept which is implemented as a practical transmission imaging (AsFTCT) for deriving mu-maps, which are the pre-requisite for proper attenuation correction. We will integrated the new technique into the design of the proposed McB system. The design and construction of the McB system will improve the state-of- the-art of body and cardiac SPECT imaging. The high performance (sensitivity and/or high spatial resolution) and the quantification capability of the proposed system could lead to improved clinical utility of cardiac imaging. Equally significant, the proposed attenuation correction techniques developed are generic and applicable to other SPECT systems. This research project should contribute broadly to the advancement of SPECT imaging toward the long-term goal of quantitative functional imaging.