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HEMATOPOIETIC PROGENITOR CELLS

HEMATOPOIETIC PROGENITOR CELLS
造血祖细胞
批准号：
2102242
负责人：
Elizabeth J Shpall
金额：
$14.77万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-09-17 至 1997-06-30
来源：
https://reporter.nih.gov/project-details/2102242
关键词：
CD antigens autologous transplantation bone marrow purging breast neoplasms cell population study clinical trials dosage drug adverse effect female growth factor hematopoietic stem cells hematopoietic tissue transplantation human subject human therapy evaluation immunocytochemistry megakaryocytes monoclonal antibody neoplasm /cancer chemotherapy neoplasm /cancer therapy tissue /cell culture

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英文摘要
Breast cancer is the most common female cancer. Its incidence is increasing rapidly in younger women, where early detection is infrequent, tumors tend to be more aggressive, and loss of productive years is greatest. High-dose chemotherapy with autologous hematopoietic progenitor cell support (AHPCS) has demonstrated effectiveness for poor-prognosis breast cancer patients. The focus of this ROl is the evaluation of AHPCS using CD34+ hematopoietic progenitor cells, which are then subjected to further manipulation(s). The goals of this project are to: l. Maximally decrease the amount of breast cancer in the autograft. 2. To produce rapid and durable marrow reconstitution in breast cancer patients receiving HDC. 3. To reduce the toxicity of infusing large volumes of unpurified AHPCS by using purified progenitor cells. 4. To develop ex vivo expansion of hematopoietic progenitors as a novel technology, and demonstrate its clinical utility.
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