COMPUTER-ASSISTED SMOKELESS TOBACCO CESSATION--PHASE II

在过去的几年里，公众对 使用无烟烟草。最近的调查估计，大约有12 数以百万计的美国人是固定用户。现在人们普遍认识到 经常使用无烟烟草产品会导致成瘾 尼古丁，而且持续使用与多种疾病有关， 其中最重要的是口腔癌。 尽管人们对无烟烟草使用的认识和关注越来越多，但非常 关于无烟戒烟的研究很少。这个 这一第二阶段项目的目标是继续努力开发一种 有效的、商业上可行的无烟烟草自助计划 停止使用一台信用卡大小的电脑-- LifeSign--最初是为吸烟而开发的自助程序 停止。LifeSign使用一台微型计算机来实现逐步退出 程序是根据用户自己的基线使用模式和 这是根据用户跟上 程序。 拟议的项目包括对软件和硬件进行修改 与基本LifeSign计划；比较LifeSign的有效性 无烟烟草计划(LSTP)，基于手动自助无烟 一项多地点随机临床试验的戒烟计划 一年的随访期；并根据临床试验的结果 试验，准备商业版本的设计规范 LSTP。

The past several years have witnessed an increased public concern over the use of smokeless tobacco. Recent surveys estimate that approximately 12 million Americans are regular users. It is now widely recognized that regular use of smokeless tobacco products results in addiction to nicotine, and that continued use is linked to a variety of diseases, the most significant of which is oral cancer. Despite a growing awareness and concern over smokeless tobacco use, very little research has been conducted on smokeless tobacco cessation. The goal of this Phase II project is to continue our efforts to develop an effective, commercially viable self-help program for smokeless tobacco cessation that is based on the use of a credit-card-size computer-- LifeSign--that was developed originally as a self-help program for smoking cessation. LifeSign uses a tiny computer to implement a gradual withdrawal program that is tailored to the user's own baseline pattern of use and that adjusts on the basis of the user's ability to keep pace with the program. The proposed project includes making software and hardware modifications to the basic LifeSign program; comparing the effectiveness of the LifeSign smokeless tobacco program (LSTP) with a manual-based self-help smokeless tobacco cessation program in a multi-site, randomized clinical trial over a one-year follow-up period; and, on the basis of results of the clinical trial, preparing a design specification for a commercial version of the LSTP.