BEHAVIORAL/COGNITIVE BEHAVIORAL TRIAL FOR COCAINE ABUSE

发展经验支持的行为和认知 可卡因滥用障碍治疗的行为策略是一个 重要的成瘾研究优先事项。 本申请提出两个 研究将评估两种有前途的方法，复发预防， (RP)和应急管理（CM），用于治疗可卡因滥用 两个人口。 研究1将比较RP和CM，单独使用和联合使用。 联合用药，用于治疗初级可卡因滥用者。 一百 将80名可卡因滥用者随机分为3组 RP手术（n = 60）、CM手术（n = 60）或其组合 RP和CM手术（n = 60）。 RP条件将由三个RP组成 每周两次RP会议，持续12周， 额外12周 CM计划将涉及相同的时间表， 门诊访视作为RP条件。 CM程序将涉及 建立一个渐进的积极强化凭单制度 在获得可卡因阴性尿样后将其递送给Ss。 研究 2将比较RP和CM单独和联合作为治疗方法， 可卡因滥用美沙酮的病人 本研究的设计为2x2 (RP通过CM），其中处理单元由所述3种条件组成 在研究1中，此外，涉及美沙酮的病症 维持治疗照常进行，没有针对可卡因的具体干预措施 虐待 200名可卡因滥用美沙酮患者将被 随机分配至四种治疗条件之一（每种条件n = 50）。 在这两项研究中，将收集以下类型的数据： 人口统计学信息和药物使用史;精神病诊断（SCID）; 治疗动机和准备度测量;药物自我报告 和酒精使用（时间线跟踪）;多维行为变化 亲社会行为改变（BCI）;身体 药物和酒精使用的措施（尿液分析和呼气酒精结果）; 艾滋病毒危险行为;治疗中的保留率;综合评分 治疗效果（TES）。 这两项研究将大大扩展 了解RP和CM治疗可卡因滥用的价值， 两个重要的可卡因滥用人群。

The development of empirically supported behavioral and cognitive behavioral strategies for the treatment of cocaine abuse disorders is an important addiction research priority. This application proposes two studies which will evaluate two promising approaches, relapse prevention (RP) and contingency management (CM), for the treatment of cocaine abuse with two populations. Study 1 will compare RP and CM, alone and in combination, for the treatment of primary cocaine abusers. One hundred eighty (180) cocaine abusers will be randomly assigned into one of 3 groups with either an RP procedure (n=60), a CM procedure (n=60) or a combination of RP and CM procedures (n=60). The RP condition will consist of three RP sessions per week for 12 weeks followed by two RP sessions per week for an additional 12 weeks. The CM program will involve an identical schedule of clinic visits as the RP condition. The CM procedure will involve the establishment of a graduated system of positive reinforcement vouchers delivered to Ss upon achievement of cocaine negative urine samples. Study 2 will compare RP and CM alone and in combination as treatment methods for cocaine-abusing methadone patients. The design of this study will be a 2x2 (RP by CM), with treatment cells consisting of the 3 conditions described in study 1 and, in addition, a condition which involves methadone maintenance treatment as usual, with no specific intervention for cocaine abuse. Two hundred (200) cocaine-abusing methadone patients will be randomly assigned to one of four treatment conditions (n=50 per condition). In both studies, the following types of data will be collected; Demographic information and drug use history; psychiatric diagnosis (SCID); measure of treatment motivation and readiness (CMRS); self report of drug and alcohol use (time line followback); multidimensional behavior change measure (ASI); a measure of prosocial behavior change (BCI); physical measures of drug and alcohol use (urinalysis and breathalcohol results); HIV risk behaviors; retention rates in treatment; composite score of treatment effectiveness (TES). The two studies will greatly expand the knowledge on the value of RP and CM for the treatment of cocaine abuse with two important cocaine-abusing population.