CELL AND MOLECULAR BIOLOGY

描述：本申请申请继续支持贝勒中国医学研究院的博士前研究培训项目。培训助学金计划基于CMB跨学科研究生计划，其中包括来自11个不同系的73名教职员工的参与。招商银行项目始于1988年秋季，有4名学生，现已发展到36名学生，到1994年5月，将有5名学生毕业。CMB项目主任Savio Woo博士是细胞生物学系和人类遗传学研究所的教授，也是霍华德·休斯医学研究所的研究员。1971年，他在华盛顿大学获得生物化学博士学位。在不列颠哥伦比亚大学完成博士后研究后，他于1973年加入贝勒学院。他的研究兴趣包括人类代谢紊乱的分子基础，开发体细胞基因治疗技术，通过胚胎干细胞的同源重组建立人类缺陷的动物模型，以及组织特异性基因表达和调控。他培养了1名研究生和30名博士后研究员，目前有2名博士后和6名博士后研究员(其中1名是吴博士实验室的研究生)在他的实验室工作。副主任苏珊·伯吉特获得了明尼苏达大学生物化学博士学位，是麻省理工学院的博士后研究员。她的研究兴趣集中在前信使核糖核酸剪接和多聚连接的分子机制上。伯吉特博士培养了8名博士后学生和3名博士后研究员，并有4名博士后学生在她的实验室工作。她将在不久的将来成为该项目的负责人。该计划的行政管理由指导委员会监督，该委员会是CMB计划的管理机构。该委员会由主任和副主任组成，每个参与的基础科学系至少有一名教员和一名CMB学生。教职员工代表中有三人是正教授，一人是副教授，三人是助理教授。该委员会制定录取标准，筛选和面试申请者，推荐录取学生，为学生提供咨询，并根据需要修改核心课程。主任担任该委员会主席，并代表CMB项目向研究生院执行委员会提交；副主任协调委员会与学生有关的活动，并代表CMB项目向研究生院促进委员会提交报告。

DESCRIPTION: This application requests continued support for a predoctoral research training program in CMB at Baylor. The training grant program is based in the interdisciplinary CMB graduate program that includes participation of 73 faculty members from 11 different departments. The CMB program, which was initiated in the fall of 1988 with four students, has grown to include 36 students, and as of May, 1994 five students will have graduated. The director of the CMB program, Dr. Savio Woo, is a Professor in the Department of Cell Biology and in the Institute for Human Genetics, and a Howard Hughes Medical Institute Investigator. He received the Ph.D. degree in biochemistry from the University of Washington in 1971. After completing a postdoctoral fellowship at the University of British Columbia, he joined the faculty at Baylor in 1973. His research interests include the molecular basis of human metabolic disorders, development of technologies for somatic gene therapy, creation of animal models of human deficiencies by homologous recombination in embryonic stem cells, and tissue-specific gene expression and regulation. He has trained 1 graduate student and 30 postdoctoral fellows, and currently has 2 predoctoral students and 6 postdoctoral fellows (1 was a graduate student in Dr. Woo's laboratory) working in his laboratory. The associate director, Susan Berget, received her Ph.D. degree in biochemistry from the University of Minnesota and was a postdoctoral fellow at Massachusetts Institute of Technology. Her research interests are focused on the molecular mechanisms of pre-mRNA splicing and polyadynlation. Dr. Berget has trained eight predoctoral students and three postdoctoral fellows, and has four predoctoral students working in her laboratory. She will become director of the program in the near future. The administration of the program is overseen by the Steering Committee which is the governing body of the CMB program. The Committee is comprised of the director and associate director, at least one faculty member from each participating basic science department and a CMB student. Three of the faculty representatives are full professors, one is an associate professor and three are assistant professors. This Committee sets admission criteria, screens and interviews applicants, recommends students for admission, counsels students, and revises the core curriculum as needed. The director chairs this Committee and represents the CMB program to the Executive Council of the Graduate School; the associate director coordinates student-related activities of the Committee and represents the CMB program to the Graduate School Promotion Committee.