BIOCHEMICAL MODEL REACTIONS

将继续开展人造酶的工作。这包括化合物 将环糊精、吡哆醛或吡哆胺与结合基团结合， 如环糊精、大环或类固醇；适当放置 碱性催化基团也将用于促进特定的过程。 酶反应的特性--对于底物，对于 化学反应，对于底物的区域，对于立体化学 底物和产物--将被模仿。硫胺素相关酶的研究进展 还将进行模拟，并将致力于合成和研究 疏水笼状分子。这些系统的设计；EMS将由 计算机建模方法。将继续进行催化剂的设计工作 使用一种新开发的检测技术来裂解RNA。对中国传统文化的研究 疏水对Diels-Alder反应及相关过程的催化作用 将追求效果和笼形催化剂，强调选择性。工作 还将致力于生产良好的模拟多肽-裂解和 合成酶。

Work on artificial enzymes will be pursued. This includes compounds combining cyclodextrins, pyridoxal or pyridoxamine with binding groups, such as cyclodextrins, macrocycles, or steroids; appropriate placement of basic catalytic groups will also be used to promote specific processes. The characteristic specificities of enzyme reactions--for substrate, for chemical reaction, for region of the substrate, and for stereochemistry of substrate and produce--will be mimicked. Work on thiamine related enzyme mimics will also be pursued, as will work on the synthesis and study of the hydrophobic cage molecules. Design of these syst;ems will be assisted by computer modeling methods. Work will be pursued on the design of catalysts that cleave RNA, using a newly developed assay technique. Studies of the catalysis of Diels-Alder reactions and related processes by hydrophobic effects and cage catalysts will be pursued, emphasizing selectivity. Work will also be directed at producing good mimics of peptide-cleaving and synthesizing enzymes.