Developing new tools for chemical biology

我们将开发新的合成策略，以支持小分子化学探针的开发，这些探针以高亲和力和特异性与靶蛋白结合。这种化学探针在阐明特定蛋白质在生物途径中的作用方面是非常宝贵的。我们的新策略旨在快速，有效地使用材料，并广泛适用于一系列不同的蛋白质靶标。我们的方法的核心是使用生物物理结合试验来检测使用平行化学小规模生产的化合物。这种方法将使更好的化学探针能够以比目前更低的成本更快地开发出来。

We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.