Optimising progress towards elimination of malaria

该项目旨在通过开发适合疾病消除建模的新工具来推进数学知识。我们将把这些新的数学工具应用于越南消除疟疾的重大问题。预期的结果是在具有个体患者特征异质性的精细空间分辨率上建立疾病消除模型的新工具，将模型校准为疾病传播的家庭水平数据，并设计干预策略以最大限度地影响疾病传播。建模，推理和优化的创新组合确保开发的数学方法将广泛适用于其他传染病的建模消除策略。

The project aims to advance mathematical knowledge by developing novel tools appropriate for modelling disease elimination. We will apply these new mathematical tools to the significant problem of malaria elimination in Vietnam. The expected outcomes are new tools for modelling disease elimination on a fine spatial resolution with heterogeneities in individual patient characteristics, calibrating models to household level data on disease transmission and designing intervention strategies for maximum effect on disease transmission. The innovative combination of modelling, inference and optimisation ensures that the mathematical methods developed will be broadly applicable to modelling elimination strategies for other infectious diseases.