The development of mid-infrared endoscopy for the detection of malignant cells and progress towards the in-vivo optical biopsy using new optical Chalc

用于检测恶性细胞的中红外内窥镜的发展以及使用新型光学 Chalc 进行体内光学活检的进展

• 批准号: 2738279
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2738279
• 关键词: development; mid; infrared; endoscopy; detection

Mid-infrared (MIR) fibre-optics, such as those comprised of Chalcogenide based glasses, have the potential to radiate wavelengths encompassing the spectral fingerprint region of biological tissue (~3-14 um). MIR absorption is known to vary dependending on molecular structure; a feature altered with diseases such as cancer. Computational analysis enables the definitive distinction between the absorption spectra of healthy and malignant cells, nullifying the need for the traditionally used and highly flawed 'Gold Standard' of histopathology for cancer detection and diagnosis. Currently MIR endoscopes are unavailable however, if developed, would enable the imaging and chemical mapping of internal issues, such as endometrium, in-vivo. This would enable an optical biopsy for cancer diagnosis in real-time, in addition to aiding surgeons post cancer diagnosis in mapping cancer margins for removal during surgery.

中红外(MIR)光纤，如那些由硫化物玻璃组成的光纤，有可能辐射涵盖生物组织光谱指纹区域(~3-14微米)的波长。众所周知，MIR的吸收随分子结构的不同而不同；这一特征会因癌症等疾病而改变。计算分析能够明确区分健康和恶性细胞的吸收光谱，消除了传统上使用的、有高度缺陷的组织病理学用于癌症检测和诊断的‘金标准’的必要性。目前还没有MIR内窥镜，但如果开发出来，将能够在体内对内部问题，如子宫内膜进行成像和化学标测。这将使光学活检能够实时诊断癌症，此外还可以帮助癌症诊断后的外科医生绘制癌症边缘图，以便在手术中切除。