Experimentally validated multiphase mathematical models of leg ulcers

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The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the formation and healing of a leg ulcer – biological processes which are currently poorly understood. The mathematical models are expected to provide new insight into the underlying biological mechanisms of leg ulcers and may ultimately improve management of chronic wounds.