Experimentally validated multiphase mathematical models of leg ulcers

经过实验验证的腿部溃疡多相数学模型

• 批准号: DE160100227
• 负责人: Prof Jennifer Flegg
• 金额: $ 26.74万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-08-15 至 2020-09-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE160100227
• 关键词: Experimentally; validated; multiphase; mathematical; models

The project is designed to develop mathematical models of the complex biological processes of leg ulcer formation and healing. The project intends to combine mathematical techniques from fluid dynamics, mathematical biology, numerical analysis and statistical inference to develop novel, multiphase, validated mathematical models that capture the complex spatiotemporal evolution of cellular and chemical species during the formation and healing of a leg ulcer – biological processes which are currently poorly understood. The mathematical models are expected to provide new insight into the underlying biological mechanisms of leg ulcers and may ultimately improve management of chronic wounds.

该项目旨在开发腿部溃疡形成和愈合的复杂生物过程的数学模型。该项目打算将流体动力学、数学生物学、数值分析和统计推断的联合收割机数学技术结合起来，开发新颖、多阶段、有效的数学模型，以捕捉腿部溃疡形成和愈合过程中细胞和化学物质的复杂时空演变-这是目前了解甚少的生物学过程。这些数学模型有望为腿部溃疡的潜在生物学机制提供新的见解，并可能最终改善慢性伤口的管理。