BIOACCUMULATION OF ENVIRONMENTAL CARCINOGENS--METHODOLOGY AND CHARACTERIZATION

来自众多研究的证据支持人类癌症和 呼吸道疾病可能是由环境污染引起的。 有 癌症高发地区之间的良好相关性， 呼吸道疾病和严重污染。 人们怀疑， 即使是中等程度的污染也会增加有害的风险。 健康影响。 大气中有机组分的生物测试 颗粒物显示出致突变和致癌活性。 然而 在试图将具体的健康影响归因于 由于环境、暴露和人口的变化而造成的污染。 一项可以显示人体内环境污染物的研究将 为这一理论提供直接证据。 该项目的目的是确定有机污染物是否可以 在脂质组织中存款和积累。 分析方法能够 检测广谱化合物将首先针对气态化合物进行优化。 样品、水样、微粒样品和脂质组织。 空气和 两个地点的水，每个地点都是一个猴子殖民地， 随着时间的推移。 一个地点相对来说是无污染的， 另一些国家的空气和水污染严重。 相关性 样本中的化合物和脂肪组织中的化合物 这两个地点的猴子数量可以提供直接证据， 化合物可能会影响人类健康。

Evidence from numerous studies support the theory that human cancers and respiratory illnesses can be caused by environmental pollution. There is a good correlation between regions with a high incidence of cancer and respiratory illnesses and high levels of pollution. It is suspect that even moderate levels of pollution can increase the risk of detrimental health effects. Biotesting of the organic fraction of atmospheric particulate has shown mutagenic and carcinogenic activity. However there is much uncertainty in trying to attribute specific health effects to pollution due to variations in environment, exposure and the population. A study which could show environmental pollutants in the human body will lend direct evidence to the theory. The purpose of this project is to determine if organic pollutants can deposit and accumulate in lipid tissues. Analytical methodology capable of detecting a broad spectrum of compounds will first be optimized for gaseous samples, water samples, particulate samples and lipid tissues. The air and water at two locations, each the site of a monkey colony, will be characterized over time. One site is relatively pollution free while the other has significant levels of air and water pollution. Correlation between the compounds found in the samples and those in the lipid tissues of monkeys at both sites could give direct evidence that environmental compounds could affect human health.