ENTOPTIC ASSESSMENT OF THE RETINAL VASCULATURE

这项研究工作的广泛长期目标是减少 戏剧性的情感，社会和经济成本的获得 由黄斑疾病引起的失明。 疾病过程 兴趣包括年龄相关性黄斑病变，获得性黄斑变性的主要原因， 美国老年人的法律的失明，以及糖尿病， 在美国工作的人中获得性失明 不幸的是，病人们， 尽管知道他们处于危险之中，但通常不知道不利的 直到视力受损 如果病人能自我- 在视力丧失之前检测视网膜事件，几个关键的临床和 实现长期目标所需的研究需求将得到满足。 这些措施包括：1）提供有关早期 视力丧失前黄斑疾病的自然史; 2）a 预防性治疗的坚实基础： 3)评估旨在改变的各种疗法的敏感手段 疾病过程的自然过程;以及4）大规模筛查和家庭 能够识别视网膜旁和中央凹的监测技术 需要进一步评估和/或治疗的缺陷。 短期 拟议研究的目的是评估 现有的优化内视镜观察技术将允许风险 患者自我检测自己的黄斑缺陷，在一个非侵入性的，成本 有效方式 这一短期目标将通过以下方式实现： 比较了I型糖尿病患者 内光学评估他们自己的中央凹和旁视网膜缺陷的缺陷 显示在患者的彩色眼底照相和荧光素 血管造影。

It is the broad long-term objective of this research effort to reduce dramatically the emotional, social and economic costs of acquired blindness caused by macular disease processes. Disease processes of interest include age-relate maculopathy, the leading cause of acquired legal blindness in older Americans, and diabetes, the leading cause of acquired blindness in working Americans. Unfortunately, patients, despite knowing they are at risk, are generally unaware of adverse retinal events until vision is compromised. If the patient could self- detect retinal events prior to a vision loss, several key clinical and research needs necessary to achieve the long-term goals would be met. these include providing: 1) fundamental information concerning the early natural history of macular disease prior to a visual acuity loss; 2) a firm foundation on which to base rationales for preventative therapies: 3) a sensitive means of evaluating various therapies designed to alter the natural course of the disease process; and 4) mass screening and home monitoring techniques capable of identifying parafoveal and foveal defects needing further evaluation and/or treatment. The short-term objective of the proposed research is to evaluate the efficacy with which existing optimized entoptic viewing techniques will allow at risk patients to self-detect their own macular defects in a noninvasive, cost efficient manner. This short term objective will be achieved by comparing the accuracy and precision with which type I diabetics can entoptically assess their own foveal and parafoveal defects to defects revealed in the patient's color fundus photography and fluorescein angiogram.