Non-animal replacement tests for acute toxicity testing

《化妆品条例》禁止化妆品及其成分在动物身上进行测试，以及禁止销售为化妆品目的而在动物身上进行测试的化妆品及其成分。这项禁令于2013年3月11日全面生效，是几十年来公众大力支持的竞选活动的高潮。这一进展现在正受到欧盟REACH法规的威胁，该法规仍要求进行某些动物试验。这种监管冲突给英国/欧盟化妆品行业带来了巨大的两难境地，并将该行业的未来置于严重威胁之下。长期以来，动物试验一直是化妆品行业一个高度情绪化的问题，也是一个主要的市场驱动力。REACH广泛支持动物试验的替代方案，但仍然需要进行动物试验，因为目前还没有经过验证的替代方案。迫切需要科学上先进、伦理上合理的非动物替代试验。项目合作伙伴将探讨开发急性毒性缓解测试的可行性，这些测试具有科学相关性，并具有足够的健壮性和重复性，可(最终)作为经合组织测试指南采用。

The Cosmetics Regulation prohibits the testing of cosmetic products and their ingredients on animals, as well as the marketing of cosmetics and their ingredients that have been tested on animals for cosmetic purposes. The ban came into full effect on 11 March 2013 and was the culmination of several decades of campaigning with huge public support. This progress is now under threat by the EU REACH regulations, which still require certain animal tests to be performed. This regulatory clash presents the UK / EU cosmetics industry with an enormous dilemma and places the future of the industry under significant threat. Animal testing has long been a highly emotive issue in the cosmetics sector and a major market driver. REACH is broadly supportive of alternatives to animal testing, but still requires animal tests where there are currently no validated alternatives available. Non-animal replacement tests are urgently needed which are both scientifically advanced and ethically sound. The project partners will explore the feasibility of developing relacement tests for acute toxicity that are scientifically relevant and sufficiently robust and reproducible for (ultimate) adoption as OECD Test Guidelines.