CORE--VIROLOGY

这个核心是艾滋病毒的中心实验室，用于检测抗病毒药物 核酶结构和转导细胞的活性。此外， 实验室将进行与临床相关的HIV-1相关监测 来自拟议的临床研究的样本。具体目标 是为了测试新的核酶特异性DNA结构， 在项目1中开发，用于抗HIV-1活动；确认抗HIV-1 项目2和项目2中执行的长期CD34+PBSC培养的活动 项目3；以及对分离产品进行艾滋病毒-1标志物分析和 应用粒细胞集落刺激因子治疗HIV-1感染者的研究 细胞集合。 扎亚博士将担任这一核心的主任。李博士将会是 HIV-1相关检测的主管。

This core serves as the central HIV laboratory for testing for antiviral activity of ribozyme constructs and of transduced cells. In addition, the laboratory will perform HIV-1 related monitoring related to clinical specimens derived from the proposed clinical studies. The specific aims of this core are to test new ribozyme-specific DNA constructions, developed in Project 1, for anti-HIV-1 activity; to confirm anti-HIV-1 activity in long-term CD34+ PBSC cultures performed in Project 2 and in Project 3; and to perform HIV-1 marker analyses on apheresis products and on HIV-1 infected subjects during and after the G-CSF administration for cell collections. Dr. J. Zaia will serve as the Director of this core. Dr. S. Li will be the supervisor of the HIV-1 related assays.