The "Personal REspiratory Disease Index Calculation Technique" Project (PREDICT)

剑桥呼吸创新有限公司（CRiL）已获得创新英国赠款，以完成基于正常潮气呼吸中CO2分析的呼吸性能指数的开发。CRiL团队开发了一种低成本的个人呼吸监测器，可以测量正常潮气呼吸中的二氧化碳。他们的目标是开发个人呼吸监测器，以帮助患有一系列呼吸系统疾病的人更好地管理他们的病情。CRiL的N-Tidal C由独特的先进外延生长LED CO2传感器供电。虽然它使用了先进的技术，但该医疗器械非常易于使用，因为它不需要强制呼气。CRiL的低成本医疗设备在正常的潮气呼吸中每秒准确测量二氧化碳浓度超过50次。CRiL的N-Tidal C最近已用于慢性阻塞性肺疾病（COPD）患者的关键探索性临床研究。呼吸记录表明，COPD患者在急性加重前约48小时开始出现呼吸记录的明显变化。通过这个研究项目，CRiL团队将为下一代个人监测器N-Tidal B开发一种自动警报，它将向患者指示他们的呼吸状况开始恶化。CRiL创新技术的开发此前得到了Innovate UK，SBRI Healthcare和一些医疗保健慈善机构的支持。

Cambridge Respiratory Innovations Limited (CRiL) has been awarded an Innovate UK grant to complete the development of a respiratory performance index based on analysis of CO2 in normal tidal breathing. The CRiL team have developed a low-cost personal respiratory monitor which measures the CO2 in normal tidal breathing. Their goal is to develop personal respiratory monitors to help people who suffer from a range of respiratory diseases to better manage their condition. CRiL's N-Tidal C is powered by a unique advanced expitaxially-grown LED CO2 sensor. Although it uses advanced technology, the medical device is very easy to use, since it requires no forced expiration. CRiL's low-cost medical device accurately measures CO2 concentrations more than 50 times per second in normal tidal breathing. CRiL's N-Tidal C has recently been used in a pivotal exploratory clinical study with patients with Chronic Obstuctive Pulmonary Disease (COPD). The breathing records demonstrate that clear changes in the breath record start to occur in COPD about 48 hours before an exacerbation. Through this research project the CRiL team will develop an automated alert for the next-generation personal monitor, the N-Tidal B, which will indicate to the patient that their respiratory condition is starting to deteriorate. The development of CRiL's innovative technology has been supported previously by Innovate UK, SBRI Healthcare and some healthcare charities.