Dual Stimulation Approach to Stem Cell Based Tissue Engineering

该项目旨在确定人类干细胞如何在导电生物材料平台上对电和机械刺激的反应中分化成不同的细胞类型，并利用这些知识开发定制的生物反应器。它希望通过创新的单细胞测量，对控制干细胞命运的机制产生新的见解，并将提供一个能够利用这些机制进行大规模干细胞分化的生物反应器。预期的结果是组织工程领域知识的重大进步和患者来源的干细胞治疗的更有效的方法。这将为改善干细胞治疗在组织工程中的应用提供新的途径。

This Project aims to determine how human stem cells differentiate into different cell types in response to electrical and mechanical stimulation on a conductive biomaterial platform, and to use this knowledge to develop a custom built bioreactor. It expects to generate new insight into the mechanisms that control stem cell fate using innovative single cell measurements, and will deliver a bioreactor capable of using these mechanisms for large scale stem cell differentiation. The expected outcomes are a significant advancement in knowledge in the field of tissue engineering and more efficient methodology for patient-derived stem cell therapy. This will provide new pathways to improving stem cell therapy for tissue engineering applications.