Developing a Biologically-realistic Model-based Approach for Generating Deep Brain Stimulation Patterns

开发基于生物现实模型的方法来生成深部脑刺激模式

• 批准号: 479824
• 负责人: Lankarany Milad
• 金额: $ 61.3万
• 依托单位: Krembil Research Institute (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479824&lang=en
• 关键词: Bio-Signal Processing; Closed-Loop Neuromodulation; Computational Neuroscience; Deep Brain Stimulation; In-Vivo Human Recordings; Movement Disorder; Optimal Pattern Generator; Optimization; Parkinson'S Disease; Stimulation Induced Synaptic Plasticity

Parkinson's disease (PD) is a debilitating movement disorder caused by the loss of dopamine in the basal ganglia. Although there is no cure for PD, symptoms of the disease can be dramatically reduced by standard deep brain stimulation (DBS) that delivers

帕金森氏病（PD）是一种由于基底神经节中多巴胺的丢失而引起的使人衰弱的运动障碍。虽然没有治愈帕金森病的方法，但标准的脑深部电刺激（DBS）可以显著减轻疾病的症状，