Responsive ‘OFF-ON’ switchable anion receptors for transmembrane transport

该项目旨在开发可切换的阴离子转运体和新的分析方法来监控这些化合物的可切换性。阴离子进入细胞被证明会引发细胞死亡，因此可以作为一种杀死癌细胞的方法。然而，为了做到这一点，转运蛋白化合物必须专门针对癌细胞，而不是影响正常细胞。如果该项目获得资助，它将提供有关转运蛋白设计(在癌细胞中开启转运蛋白)的新的基础知识，这将适用于基于转运蛋白的疗法的未来发展。它还将在澳大利亚和西班牙的成功合作中为PDRA、博士和荣誉学生提供跨学科培训机会。

The project aims to develop switchable anion transporters and new assays to monitor the switchability of these compounds. Anion transport into cells has been shown to trigger cell death and so could be used as a method of killing cancer cells. However in order to do this the transporter compounds must target cancer cells specifically and not affect normal cells. Should this project be funded it will provide new fundamental knowledge on transporter design (switching transport on in cancer cells) which will be applicable to the future development of transporter-based therapeutics. It will also also provide interdisciplinary training opportunities for a PDRA, PhD and Honours students in a successful Australia-Spain collaboration.