MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASES

描述：本提案的目标是开发、扩展和 加强谱系数据的似然分析方法，包括 分离和连锁分析。这将使用PAP完成， 谱系分析包，一系列已被 在过去的15年里不断发展和改进。有四个具体的 每个项目有两个具体的目标。第一个目标是 开发新的算法来模拟线粒体遗传， 模拟选择的效果。第二个目标是开发新的方法 筛选多位点对表型的影响， 基于模拟的拟合优度测试。第三个目标是扩大 当前的程序实现更新的确定校正方案， 并合并复制和同卵双生子数据。最终目标是 为科学界分发、支持和更新PAP，以及 开发整个PAP包的第5版。

DESCRIPTION: The goal of the present proposal is to develop, extend, and enhance methods of likelihood analysis of pedigree data, including both segregation and linkage analysis. This will be done using PAP, the Pedigree Analysis Package, a series of Fortran programs that have been developed and modified over the past 15 years. There are four specific aims, each with two specific projects. The first aim involves developing new algorithms to model mitochondrial inheritance and to model the effect of selection. The second aim is to develop new methods of screening for multilocus effects on phenotypes and to develop simulation-based goodness-of-fit tests. The third aim is to extend current programs to implement a newer ascertainment correction scheme, and to incorporate replicate and MZ twin data. The final aim is to distribute, support, and update PAP for the scientific community, and to develop revision 5 of the entire PAP package.