EPIDEMIOLOGY OF MALE INFERTILITY--CRYPTORCHIDISM

隐睾症可能是男性不育的一个主要原因，尽管有 以前的单侧或双侧隐睾症没有对照研究 男性。目前尚不清楚生育率是否与年龄有关 隐睾症的治疗、术前睾丸定位及治疗 前处理浆料。没有证据表明兰花固定术会影响 随后的生育能力。尽管缺乏证据，但目前的 建议在2岁前纠正隐睾症的年龄几乎是普遍的 109.91接受。 有2000名以前是隐睾科的男性，现在21岁或 在儿童时期在儿童医院做过手术的老年人 匹兹堡在1955至1984年间。这个组是独一无二的，因为它包括 一大群在2岁或更小的时候做过手术的患者 即使在接受治疗的人中，也可以评估与治疗年龄的关系 在很小的时候。在这一队列中，估计将有900人 已婚，能够联系并愿意参加评估 亲子关系的问题。 本项目将对这些主题进行评估，以确定： 1.如果以前表现为亲子关系的不孕不育减少 单侧和双侧隐睾症。 2.治疗前的年龄是否与年龄有关 睾丸的位置、大小、活检和亲子关系。 第一部分将使用外部控制，有生育能力的受试者将服务 作为第二部分的内部控制。 患者的可用性已被确定为人群中的一部分； 在预计的3750名受试者中，有2145名已经从 最近25年的30年期间，从1955年到1984年。这项研究 调查人员是那些参与了一项非常成功的 原儿童医院糖尿病患者的流行病学研究 糖尿病。一项对350份病历的初步研究证实了 研究对象的可用性和数据的可靠性。25个科目的子集 已与初步数据收集联系，以演示采样 数据和保证数据是可以获得的。 这项研究将评估隐睾症的生育力，并确定 治疗双侧或单侧隐睾会影响生育。

Cryptorchidism is likely a major cause of male infertility, although there are no controlled studies of formerly unilateral or bilateral cryptorchid males. It is not known whether fertility is related to the age of treatment of cryptorchidism, pretreatment testicular location and pretreatment size. There is no evidence that orchidopexy effects subsequent fertility. In spite of the lack of evidence, the current recommended age to correct cryptorchidism by age 2 is virtually universally accepted. There is a cohort of 2000 formerly cryptorchid males now 21 years of age or older who had surgery during childhood at The Children's Hospital of Pittsburgh between 1955 and 1984. This group is unique because it includes a large group of patients who had surgery at age 2 or younger so the relationship to age of treatment can be assessed even among those treated at very young ages. In this cohort it is estimated that 900 will be married, able to be contacted and willing to participate in an assessment of paternity. This project will evaluate these subjects to ascertain: 1. If infertility expressed as paternity is decreased in formerly unilateral and bilateral cryptorchid. 2. If there is a relationship between the age of treatment pretreatment testicular location, size, the presence of a biopsy and paternity. External controls will be used for portion one, fertile subjects will serve as internal controls in portion two. Patient availability has been ascertained to a subset of the population; 2145 subjects of the projected 3750 have been identified from the most recent 25 years of the 30 year period from 1955 to 1984. The research investigators are those who have been involved in a very successful epidemiologic study of former Children's Hospital patients with diabetes mellitus. A pilot study of 350 medical history records has verified the availability of subjects and reliability of data. A subset of 25 subjects have been contacted with initial data collection demonstrating a sampling of data and reassurance that data can be obtained. This study will, evaluate fertility in cryptorchidism and determine if treatment of bilateral or unilateral cryptorchidism effects fertility.