Lipopolysaccharide-induced macrophage extracellular traps in host defence

先天免疫系统是抵御微生物入侵的第一道防线。巨噬细胞是关键的先天性免疫细胞，可以部署抗菌反应以清除感染并恢复健康。在驱动巨噬细胞炎症和抗菌途径的分子机制上有许多关键的未回答的问题。该项目旨在阐明一种新的炎症机制，该机制通过新发现的由垂死的巨噬细胞制成的称为细胞外陷阱的结构来固定和杀死入侵的细菌。我们通过询问这种称为非典型炎性体的免疫细胞信号传导途径获得的见解将为我们对哺乳动物炎症和抗微生物反应的基本理解增加有价值的知识

The innate immune system is the first line of defence against invading microbes. Macrophages are key innate immune cells that deploy antimicrobial responses to clear infection and restore health. There are many critical unanswered questions on the molecular mechanisms that drive macrophage inflammatory and antimicrobial pathways. This project aims to elucidate a novel inflammatory mechanism that immobilises and kills invading bacteria via newly discovered structures made by dying macrophages called extracellular traps. Insight we gain by interrogating this immune cell signalling pathway, called the non-canonical inflammasome, will add valuable knowledge to our fundamental understanding of mammalian inflammation and anti-microbial responses