CORE--VIROLOGY

这个核心作为艾滋病毒的中心实验室，用于检测抗病毒药物 核酶构建体和转导细胞的活性。 此外该 实验室将进行与临床相关的HIV-1相关监测 来自拟定临床研究的标本。 具体目标 是测试新的核酶特异性DNA结构， 在项目1中开发，用于抗HIV-1活性;以确认抗HIV-1 在项目2中进行的长期CD 34 + PBSC培养物中的活性， 项目3;对单采血液成分产品进行艾滋病毒1型标志物分析， HIV-1感染受试者在G-CSF给药期间和之后， 细胞收集。 博士J. Zaia将担任该核心的主任。 Dr. S.李将 HIV-1相关检测的主管。

This core serves as the central HIV laboratory for testing for antiviral activity of ribozyme constructs and of transduced cells. In addition, the laboratory will perform HIV-1 related monitoring related to clinical specimens derived from the proposed clinical studies. The specific aims of this core are to test new ribozyme-specific DNA constructions, developed in Project 1, for anti-HIV-1 activity; to confirm anti-HIV-1 activity in long-term CD34+ PBSC cultures performed in Project 2 and in Project 3; and to perform HIV-1 marker analyses on apheresis products and on HIV-1 infected subjects during and after the G-CSF administration for cell collections. Dr. J. Zaia will serve as the Director of this core. Dr. S. Li will be the supervisor of the HIV-1 related assays.