iDx-LUNG - Integrating non-invasive diagnostics into NHSE Lung Health Checks in Wessex and Yorkshire

IDX肺计划汇集了一个由学术机构、NHS英格兰肺部健康检查系统和五个商业合作伙伴组成的财团，以加快肺癌早期诊断的进展。来自韦塞克斯、约克郡和曼彻斯特的7000名在社区移动CT扫描仪前接受肺部健康检查的人将被要求提供血液样本和从鼻子内采集的细胞进行检测。我们将分析样本中是否存在可能表明癌症早期发展的变化：抗癌蛋白抗体；癌症相关蛋白水平升高；癌症循环DNA，以及鼻衬细胞中基因表达的变化。所有这些测试都是由不同的公司开发的，但从未与CT扫描结合使用，以确定哪种测试可能在发现早期肺癌方面最有效。我们将把所有这些测试的数据合并到一个具有复杂分析能力的单一数据库中，以便联盟中的合作伙伴能够以任何最合适和信息丰富的方式可视化结果。通过这样做，我们将建立最佳方法来选择要调查的人，无论是进行初始CT扫描，还是在CT扫描结果不清楚的情况下进行进一步调查。我们希望简化癌症检测过程，并减少发现每个新病例所需的NHS资源。

The iDx-Lung programme brings together a consortium of academic institutions, NHS England Lung Health Checks and five commercial partners to accelerate progress in the early diagnosis of lung cancer. 7000 people from Wessex, Yorkshire and Manchester attending for lung health checks at mobile CT scanners in the community will be asked to give samples of blood, and cells collected from inside the nose, for testing. We will analyse the samples for the presence of changes that may indicate the presence of early cancer development: antibodies against cancer proteins; raised levels of cancer-related proteins; circulating DNA from cancers, and changes in the expression of genes in the cells lining the nose. All of these are tests which have been developed by different companies but never used in combination or with CT scanning, to see which might be the most efficient at finding early lung cancers. We will combine the data from all these tests into a single database with complex analytical capabilities in order to allow the partners in the consortium to visualise the results in whichever way is most appropriate and informative. By doing this we will establish the best way to select people for investigation, either for initial CT scans, or for further investigation if the CT scan findings are not clear. We hope to streamline the process of detecting cancers and reduce the NHS resources that are needed in order to find each new case.