SEATTLE FICSIT STUDY ANALYSIS

拟议研究的长期目标是了解 运动对老年人健康状况的影响，以促进 健康状况和减少与跌倒有关的伤害， 安全锻炼计划。 具体目标是：（1）确定和 比较力量训练（ST）、耐力训练（ET）和 联合力量/耐力训练（ET+ST）对肌肉力量，有氧 能力、步态、平衡、功能状态和跌倒风险;（2） 确定运动效果是否在运动后持续3个月;（3） 深入了解运动对功能的影响机制， （4）确定与参与有关的因素， 锻炼计划。 在某种程度上，这项研究假设， 可以大大改善健康状况指标， 改善将与强度变化相关。 本研究为随机对照试验。 主要资格标准 年龄在68-85岁之间，腿部无力与健康受损相关 增加跌倒风险。 受试者将从经过充分研究的 一群老年人加入了健康维护组织。 通过多阶段筛选， 大约750名成年人，研究计划将100人随机分为四组， ST组、ET组、ST+ET组及对照组。 预计会有20%的流失率， 最终样本量为80（每组10名男性和10名女性）。 行使 约1小时的会话将每周进行三次，持续6个月。 ST将 开始在低水平使用手臂和脚踝的重量，然后推进到使用一个 环球健身房 ET将是涉及手臂和腿的自行车运动。 评价设计为三次测量的重复测量设计 场合：预测试，后测试，和后续测试（在3个月后， 锻炼）。 力量将在脚踝，膝盖，臀部，肘部和 手腕使用等速测力计。 不同姿势下的摇摆 将使用测力平台测量应力条件。 步态测量将在步态实验室中使用测力平台进行 和导电走道，并包括步态事件和地面的测量 反作用力 次极量跑台和自行车有氧能力 运动将被衡量。 一般健康状况将使用 经验证的调查表措施。 统计分析将使用程序 与重复测量MANOVA协变量相关，如配对t- 测试，并重复测量方差分析。

The long-term objective of the proposed research is to understand the effects of exercise on the health status of older adults, so as to promote health status and reduce fall-related injuries through carefully designed, safe exercise programs. The specific aims are: (1) to determine and compare the effects of strength training (ST), endurance training (ET), and combined strength/endurance training (ET+ST) on muscle strength, aerobic capacity, gait, balance, functional status, and fall risk; (2) to determine if effects of exercise persist 3 months post-exercise; (3) to gain insight into the mechanism of effects of exercise on functional status; and (4) to identify factors associated with participation in the exercise program. In part, the study hypothesizes that exercise training can produce substantial improvements in health status indicators, and that improvement will correlate with changes in strength. The study is a randomized controlled trial. The major eligibility criteria are age 68-85 and leg weakness at a level associated with impaired health and increased fall risk. Subjects will be recruited from a well-studied group of older adults enrolled in an HMO. By multi-stage screening of about 750 adults, the study plans to randomize 100 persons to one of four groups: ST, ET, ST+ET, and control. A 20% attrition rate is anticipated, giving a final sample size of 80 (10 men and 10 women per group). Exercise sessions of about 1 hour will occur three times/week for 6 months. ST will begin at low levels using arm and ankle weights, then advance to use of a Universal Gym. ET will be bicycle exercise involving both arms and legs. The evaluation design is a repeated measures design with three measurement occasions: pretest, posttest, and follow-up test (at 3 months post- exercise). Strength will be measured at the ankle, knee, hip, elbow, and wrist using an isokinetic dynamometer. Postural sway under different stress conditions will be measured using a force measurement platform. Measures of gait will be made in a gait laboratory using a force platform and a conductive walkway, and include measures of gait events and ground reactive forces. Aerobic capacity at submaximal treadmill and bicycle exercise will be measured. General health status will be measured using validated questionnaire measures. Statistical analysis will use procedures related to repeated measures MANOVA with covariates, such as paired t- tests, and repeated measures ANOVA.