CORE--VIROLOGY CORE LABORATORY

此应用程序的目的是展示 俄亥俄州州立大学艾滋病临床试验单位的病毒学实验室， 作为ACTU网络的核心病毒学实验室之一。 该ACTG实验室将执行方案病毒学监测， 由ACTG协议和病毒学核心委员会授权。 这些包括 艾滋病毒抗原检测、艾滋病毒培养以及 其他病毒标志物作为诊断方法的发展。 参与质量 保证程序将标准化和验证化验结果。 先前进行大量这些测定的经验， 保持高水平的熟练程度和质量控制， 过去三年证明了该实验室的能力， 这项工作 OSU ACTU病毒学实验室是/不是主要组织 作为一个基础研究实验室做实验研究， 实验室开发标准化检测。 这个概念最重要 在进行方案规定的病毒学检测时， 在大样本上使用一致性检测提供一致准确的结果， 样本数量。 各种实验室认证 各组织证明实现了这一目标。 然而，实验室 在病毒学的应用和发展方面仍然表现良好 在临床环境中进行检测，目前正在参与 评价新的定量病毒学培养技术。 此外，病毒学设施最近建成， 预期功能会有所扩展。 因此，空间和 设备足以安全处理预期增加的样本 即可.

The purpose of this application is to demonstrate the capability of The Ohio State University AIDS Clinical Trials Unit's virology laboratory to function as one of the core Virology Laboratories for the ACTU network. This ACTG laboratory will perform the protocol virologic monitoring as mandated by the ACTG protocols and Virology Core Committee. These include HIV antigen testing, HIV cultures and the measurement and evaluation of other viral markers as diagnostic methods evolve. Participation in quality assurance programs will standardize and validate assay results. Prior experience in the performance of a large number of these assays and the maintenance of a high level of proficiency and quality control for the last three years attests to the capability of this laboratory to perform this work. The OSU ACTU virology laboratory was/is not primarily organized as a basic research laboratory doing experimental studies ut as a clinical laboratory developing standardized assays. This concept is most important in performing the protocol mandated virologic assays where the goal is providing consistently accurate results using a consensus assay on a large number of specimens. Laboratory certifications from a variety of organizations attests to achieving this goal. Nevertheless the laboratory still has performed well in the application and development of virologic assays in the clinical setting and currently participates in the on-going evaluation of new quantitative virologic culture techniques. In addition, the virology facilities were recently constructed and were built with an expansion in function expected. Thus, both space and equipment are ample to safely handle the expected increase in specimen load.