PSYCHOSOCIAL FACTORS & NEUROENDOCRINE FUNCTION IN AGING

该NIA-SERCA在行为老年医学中的应用目的是 为申请人提供神经内分泌学培训， 她现有的心理社会流行病学和老龄化方面的专业知识。 等 培训将允许申请人追求她的兴趣， 心理社会因素在老化的轨迹，特别是 假设这些因素可能影响 随着年龄的增长，健康和功能的模式是通过他们的调制 神经内分泌对刺激的反应模式。 这个SERCA 申请旨在为申请人提供必要的 知识和研究技能，以追求她的直接职业目标， 制定了一系列研究方案， 自尊、个人控制和社会支持等特征 下丘脑-垂体-肾上腺轴反应的不同模式 “挑战”。 拟议的SERCA培训方案包括： 神经内分泌学的课程作业和实验室研究培训 和神经解剖学为申请人提供必要的知识 以及开发和实施此类研究的技能。 理查德·罗宾斯博士 神经内分泌学家，将作为申请人的担保人， 主要导师; Caleb Finch博士，神经生物学家，特别是 她将成为她的神经解剖学导师;伯顿博士 辛格是一名生物统计学家， 而心理学家凯伦·马修博士将担任 作为研究设计和仪器问题的导师/顾问 将心理社会因素与生理“反应”模式联系起来。 就长期职业目标而言，拟议的SERCA培训将 为申请人提供独特的技能组合， 神经内分泌学和心理社会流行病学 追求她的兴趣，开发一个多学科的计划， 关于衰老的研究，其中包括神经内分泌参数沿着 与心理社会因素，“疾病”状态和功能能力， 老化的模型。 申请人所在部门大力支持 这一目标，因为它符合更大的学校范围内的发展目标 更多的跨学科研究 综合了社会心理和生理参数。 的 申请人独特的技能组合，桥接学科， 神经内分泌学和心理社会流行病学，将使她能够 在制定这样的研究计划中发挥主导作用。 因此 拟议的SERCA培训将是申请人能力的核心， 在她所选择的研究领域内发展成为一名独立的科学家 关于衰老

The purpose of this NIA-SERCA application in behavioral geriatrics is to provide the applicant with training in neuroendocrinology to complement her existing expertise in psychosocial epidemiology and aging. Such training will permit the applicant to pursue her interest in the role of psychosocial factors in trajectories of aging, specifically the hypothesis that one of the ways in which such factors may influence patterns of health and functioning with age is through their modulation of patterns of neuroendocrine response to stimuli. This SERCA application is designed to provide the applicant with the necessary knowledge and research skills to pursue her immediate career goal of developing a series of research protocols to examine the influence of characteristics such as self-esteem, personal mastery and social support on differential patterns of hypothalamic-pituitary-adrenal axis response to "challenge". The proposed SERCA program of training incorporates both coursework and laboratory research training in neuroendocrinology and neuroanatomy to provide the applicant with the requisite knowledge and skills to develop and implement such studies. Dr. Richard Robbins, a neuroendocrinologist, will serve as the applicant's sponsor and primary mentor; Dr. Caleb Finch, a neurobiologist with particular expertise in aging, will be her mentor for neuroanatomy; Dr. Burton Singer, a biostatistician, will provide training in statistical analysis of "reactivity" data while Dr. Karen Matthew, a psychologist, will serve as a mentor/consultant on study design and instrumentation issues relating psychosocial factors to patterns of physiologic "reactivity". In terms of longterm career goals, the proposed SERCA training would provide the applicant with a unique combination of skills in both neuroendocrinology and psychosocial epidemiology which would enable her to pursue her interest in developing a multidisciplinary program of research on aging which incorporates neuroendocrine parameters along with psychosocial factors, "disease" status and functional abilities in models of aging. The applicant's department is strongly supportive of this goal as it fits within the larger school-wide goal of developing more multidisciplinary research greater interdisciplinary research which incorporates both psychosocial and physiologic parameters. The applicant's unique combination of skills, bridging the disciplines of neuroendocrinology and psychosocial epidemiology, would enable her to take the lead role in developing such a program of research. Thus, the proposed SERCA training would be central to the applicant's ability to develop as an independent scientist within her chosen area of research on aging.