CAPILLARY OPTICS TO CONTROL NEUTRONS FOR BNCT

硼中子俘获疗法是一种两组分的治疗方法。它是基于 选择性地将含硼药物输送到癌组织， 然后用热中子照射，然后由 硼原子核。将开展合作努力，开发一种 能够发射经过过滤的聚焦热束的中子枪 中子。这将提供一种局部治疗方式， 节省对健康组织的剂量。中子枪是基于使用一种 一项新技术，毛细管中子光学，最近展示了 冷中子的显著通量增强。基于以下方面的建模 毛细光学的实验测量将被用来确定 设备与各种加速器配合使用时的可行性 基于反应堆的中子源。项目团队包括以下方面的专家 中子光学、中子源、慢化剂设计和建模以及硼 中子俘获疗法。中子枪将特别有益于 手术床大体切除后的术中处理 切除皮肤、乳腺、肉瘤和转移性病变等肿瘤， 通常需要常规辐射的局部剂量增加 治疗。中子输送系统也将有利于 眼部黑色素瘤暴露后的术中处理。

Boron Neutron Capture Therapy is a two component modality. It is based on selective delivery of a boronated pharmaceutical to cancerous tissue, followed by irradiation with thermal neutrons and subsequent capture by the boron nuclei. A collaborative effort will be undertaken to develop a neutron gun capable of delivering a filtered, focused beam of thermal neutrons. This will provide a local treatment modality which is extremely dose-sparing to healthy tissue. The neutron gun is based on the use of a new technology, capillary neutron optics, which has recently demonstrated significant flux enhancements for cold neutrons. Modeling based on experimental measurements of capillary optics will be used to determine the feasibility of the device when paired with a variety of accelerator or reactor based neutron sources. The project team includes experts in neutron optics, neutron sources, moderator design and modeling, and boron neutron capture therapy. The neutron gun will be of particular benefit for intraoperative treatment of the surgical bed following gross total resection of tumors such as skin, breast, sarcoma and metastatic lesions, which typically require a local dose boost with conventional radiation treatment. The neutron delivery system will also be advantageous for intraoperative treatment after exposure of ocular melanoma.