Mathematical Modelling of the Mechanobiology of Arterial Plaque Growth

斑块生长是由动脉中内皮细胞、脂质、单核细胞/巨噬细胞、平滑肌细胞和血小板之间的相互作用诱导的慢性炎症反应。它涉及许多不同的生物过程，如脂质沉积、炎症和血管生成，以及它们与微循环的相互作用。为了了解潜在的机械生物学，我们建议开发一个数学模型来解释斑块的生长，通过整合这些动态的生物过程。它将提供一个系统的理性认识斑块的增长。将提供新的模型，以更好地解释生物学数据，并有助于我们量化生长和发育过程中复杂的生物学机制的知识。

Plaque growth is a chronic inflammatory response induced by the interactions between endothelial cells, lipids, monocytes/macrophages, smooth muscle cells and platelets in the arteries. It involves many different biological processes, such as lipid deposition, inflammation and angiogenesis, and their interactions with the microcirculation. To understand the underlying mechanobiology, we propose to develop a mathematical model to interpret plaque growth by integrating these dynamic biological processes. It will offer a systematic rational understanding of plaque growth. New models will be provided to better interpret biological data and contribute to our knowledge in quantifying complex biological mechanisms during growth and development.