FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER

此申请是为临床医生颁发的科学家发展奖 (国家发改委)加强首席调查员在人类方面的研究培训 遗传学及其在重症慢性阻塞性肺疾病研究中的应用 儿童和青少年的精神病理学。请求提供资金以 自由时间进行教学和合作研究 这片区域。导师将是Michael Boehnke博士，副教授 密歇根大学生物统计学教授。 国家发改委活动的科学焦点将是强迫症 精神障碍(0CD)。0CD是一种常见的精神综合征，通常始于 在童年，坚持到成年，并聚集在家庭中。它 在临床表现上相对一致 寿命。最近的家庭研究表明，一种形式的0CD与 Gilles de la Tourette综合征的基因。家庭研究使用 目前的诊断程序和分析方法是必要的 探讨OCD可能的表达和传播方式 在家庭中。家族性病例对照研究的总体目标描述 在这方面的应用是为了系统地评估和比较临床 儿童、青少年和儿童的特征和家庭精神病史 成年先驱者有0CD。假设(1)早发的0CD是 男性多于女性；(2)0CD的患病率为 早发性0CD先证者亲属高于先证者 晚发性0CD先证者的亲属，(3)0CD的遗传方式为 受单个主基因座影响；(4)慢性抽动障碍 常见于男性CD先证者；(5)慢性抽动的患病率 女性先证者亲属的精神障碍高于女性先证者 男性先证者的亲属。将检查该数据是否有其他 研究结果，包括与匹配的正常对照组和他们的 亲戚。总而言之，这项研究将增进我们对 0CD的病因学，将为科学发展提供媒介 首席调查员的名字。

This application is for a Scientist Development Award for Clinicians (SDAC) to further the principal investigator's research training in human genetics and its application to the study of severe, chronic psychopathology in children and adolescents. Funding is requested to free time to pursue didactic instruction and collaborative research in this area. The preceptor will be Michael Boehnke, Ph.D., Associate Professor of Biostatistics at the University of Michigan. The scientific focus for SDAC activities will be obsessive-compulsive disorder (0CD). 0CD is a common psychiatric syndrome that often begins in childhood, persists into adulthood, and aggregates in families. It is relatively consistent in its clinical presentation across the lifespan. Recent family studies indicate that a form of 0CD is related genetically to Gilles de la Tourette syndrome. Family studies using current diagnostic procedures and analytic methods are necessary for investigating the possible modes of expression and transmission of 0CD in families. The general aim of the family case-control study described in this application is to systematically assess and compare the clinical characteristics and family psychiatric history of child, adolescent, and adult probands with 0CD. It is hypothesized that (1) early-onset 0CD is more frequent in males than in females, (2) the prevalence of 0CD is higher in the relatives of probands with early-onset 0CD than in the relatives of probands with late-onset 0CD, (3) the inheritance of 0CD is influenced by a single major locus, (4) chronic tic disorders are more frequent in male 0CD probands, and (5) the prevalence of chronic tic disorders is higher in the relatives of female 0CD probands than in the relatives of male 0CD probands. The data will be inspected for other findings, including comparisons with matched normal controls and their relatives. In summary, this study will advance our knowledge of the etiology of 0CD, and will provide a medium for the scientific development of the principal investigator.