FAMILY STUDY OF OBSESSIVE COMPULSIVE DISORDER

这项研究将确定是否强迫症（OCD） 是家族性的 考虑到《公约》的不一致性和方法上的局限性， 在先前的研究中，我们提出了一个盲法对照家庭研究。 其他目的包括：确定是否有其他特定的精神病 在强迫症先证者的一级亲属中， 识别人口统计学和临床特征 区分家族性和散发性（非家族性）强迫症病例; 进行离析分析。 强迫症先证者将在巴尔的摩的四个机构中确定， 华盛顿，华盛顿特区将设立一个年龄、性别和种族匹配的对照组， 在每个先证者的住宅区都能找到。 所有先证者， 控制，他们的一级亲属将直接和盲目 使用标准化仪器进行检查，以诊断DSM-IIIR轴I， 轴II精神障碍。 最终的诊断将通过协商一致作出 两名独立的精神病学家审查所有案件材料，包括 医疗记录 有多名成员患有强迫症的家庭将被 未来可能的遗传连锁研究。

This research will establish whether obsessive compulsive disorder (OCD) is familial. Given the inconsistencies and methodological limitations of prior research, we are proposing a blinded, controlled family study. Additional aims include: determining if other specific psychiatric disorders are more prevalent in first-degree relatives of OCD probands than those of controls; identifying demographic and clinical features which distinguish familial from sporadic (non-familial) cases of OCD; and conducting segregation analysis. OCD probands will be identified in four institutions in Baltimore and Washington, D.C. A control group, matched on age, sex, and race, will be identified in the residential neighborhood of each proband. All probands, controls, and their first-degree relatives will be directly and blindly examined using a standardized instrument to diagnose DSM-IIIR Axis I and Axis II psychiatric disorders. Final diagnoses will be made by consensus of two independent psychiatrists reviewing all case material, including medical records. Families with multiple affected members with OCD will be identified to possible future genetic linkage study.