BRAIN ERPS AND COGNITIVE DEMAND IN SCHIZOPHRENIA

精神分裂症患者表现出P30O波幅的降低， 脑事件相关电位（ERP）的音调，这已被报道， 在某些研究中，左颞区最大。我们的初步 一项研究重复了这一发现， 两耳词的优势，这是最显着的精神分裂症 有阳性症状的患者。本项目旨在确定 认知任务对P300降低和不对称性的要求 精神分裂症患者P3OO异常与两耳分听的关系 收听对症状特征的不对称性（即，思维障碍和 幻听）、性别和家庭传播 精神分裂症一个更长远的目标是确定潜在价值 脑ERPs作为常规治疗反应的预测因子 抗精神病药或氯氮平。 ERP任务要求将使用口头（无意义音节）和 非语言（复杂的音调）刺激在简单的双耳“古怪”任务和 更困难的双耳分听任务。ERP和行为反应 将记录90例精神分裂症患者和30例正常对照者的脑电活动。 患者将在至少4周的停药期后接受检测， 氟哌啶醇治疗6周后。治疗无应答者， 接受氯氮平将重新测试后6周再次对这种药物。 此外，至少有30名精神分裂症患者的ERP在 未给药期和所有正常对照将在 连续单词识别任务，被认为反映了左内侧 颞叶功能将在几个方面获得临床评级 量表包括：阳性和阴性症状量表，思维障碍 索引和BPRS。听觉感知中的ERP和行为测量 和记忆任务应该产生收敛的证据来评估 关于存在左颞叶缺陷的假设， 精神分裂症阳性反应亚型 精神抑制剂

Schizophrenic patients have shown a reduction in the amplitude of the P30O brain event-related potential (ERP) to tones, which has been reported to be maximal over the left temporal region in some studies. Our preliminary study replicated this finding and found evidence of reduced left brain dominance for dichotic words, which was most marked in schizophrenic patients with positive symptoms. This project aims to determine the effect of cognitive task demands on P300 reduction and asymmetry in schizophrenia, and to examine the relation of abnormal P3OO and dichotic listening asymmetry to symptom features (i.e., thought disorder and auditory hallucinations), gender and familial transmission of schizophrenia. A more long range goal is to determine the potential value of brain ERPs as predictors of therapeutic response to a conventional neuroleptic or to clozapine. ERP task demands will be manipulated using verbal (nonsense syllable) and nonverbal (complex tone) stimuli in easy binaural "oddball" tasks and in more difficult dichotic listening tasks. ERPs and behavioral responses will be recorded in 90 schizophrenic patients and 30 normal controls. Patients will be tested after a minimum 4 week drug-free period and again after 6 weeks of treatment with haloperidol. Treatment nonresponders who receive clozapine will be retested again after 6 weeks on this medication. In addition, ERPs of at least 30 of the schizophrenic patients in the unmedicated period and all normal controls will be measured during a continuous word recognition task, which is thought to reflect left medial temporal lobe function. Clinical ratings will be obtained on several scales including: Positive and Negative Syndrome Scale, Thought Disorder Index, and BPRS. ERP and behavioral measures in the auditory perception and memory tasks should yield converging evidence for evaluating hypotheses concerning the existence of left temporal lobe deficits in a subtype of schizophrenia with positive symptoms and distinctive response to neuroleptics.