OMEGA-3 FATTY ACIDS AND CARDIOVASCULAR RISK FACTORS

心血管疾病仍然是美国的头号死因。 最近的临床和实验室研究表明， ω-3多不饱和脂肪酸（鱼油）在心血管疾病中的作用。 许多鱼油研究已经证明可以降低血压， 血脂、血小板计数和血小板聚集。 海洋石油或 ω-3脂肪酸、二十碳五烯酸（EPA）和二十二碳六烯酸 (DHA)似乎是可以有利地改变这些的主要成分， 这些因素可能与心血管疾病有关。 初步研究表明，对欧米茄的放松反应- 3脂肪酸、DHA和EPA在离体大鼠主动脉中的含量。 有非常 从文献中获得的关于直接血管效应的数据很少 omega-3脂肪酸，没有报告确定直接血管效应 在存在心血管危险因素的情况下，omega-3脂肪酸的含量。 这些危险因素包括高血压、年龄、吸烟， 血液胆固醇水平升高。 因此，具体目标， 将检验DHA和EPA诱导血管舒张的假设， 在某种程度上，解释了omega-3的保护和/或预防作用 脂肪酸在心血管疾病中的作用是：定义和比较 DHA和EPA对大鼠血管组织的血管作用随着年龄的增长， 确定ω-3脂肪酸诱导的大鼠血管反应， 高血压诱导饮食，检查钙介导的血管效应 的DHA和EPA在正常血压大鼠，并比较钙介导的 高血压大鼠中ω-3脂肪酸的血管反应。 将采用胸主动脉的体外隔离浴灌注， 评估血管张力的变化。 将平衡容器， 在最佳条件下，在Krebs-Ringer碳酸氢盐缓冲液中60-90分钟 张力 将测量等轴力和累积浓度- 将产生对ω-3脂肪酸的响应曲线。 通过 确定ω-3脂肪酸对血管的影响， 用于疾病治疗，即可以开发饮食调整。 的 拟议的研究将支持和改善目前的护理实践， 可能启动二级和三级预防战略， 心血管疾病

Cardiovascular disease remains the number one cause of death in America. Recent clinical and laboratory investigations suggest a protective role for omega-3 polyunsaturated fatty acids (fish oils) in cardiovascular disease. Numerous fish oil studies have demonstrated a reduction in blood pressure, serum lipids, platelet count and platelet aggregation. The marine oils or omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) appear to be the main components which can favorably alter these factors that may be associated with cardiovascular disease. Preliminary investigations have demonstrated relaxation responses to omega- 3 fatty acids, DHA and EPA in the isolated rat aorta. There are very little data available from the literature on the direct vascular effects of omega-3 fatty acids and no reports establishing the direct vascular effects of omega-3 fatty acids in the presence of cardiovascular risk factors. These risk factors include hypertension, age, cigarette smoking, and elevated levels of blood cholesterol. Therefore, the specific aims that will test the hypothesis that vascular relaxation induced by DHA and EPA way, in part, explain the protective and/or preventive role of omega-3 fatty acids in cardiovascular disease are to: define and compare the vascular effects of DHA and EPA on rat vascular tissue with increased age, determine the omega-3 fatty acids-induced vascular responses in rats fed a hyperlipidemia-inducing diet, examine the calcium-mediated vascular effects of DHA and EPA in normotensive rats, and compare the calcium-mediated vascular responses of omega-3 fatty acids in hypertensive rats. In vitro isolated bath perfusion of the thoracic aorta will be employed to assess changes in vascular tension. The vessels will be equilibrated for 60-90 minutes in Krebs-Ringer bicarbonate buffer solution under optimal tension. Isometric force will be measured and cumulative concentration- response curves to the omega-3 fatty acids will be generated. By determining the vascular effects of omega-3 fatty acids, a valid foundation for disease treatment, i.e. dietary modification can be developed. The proposed research will support and improve current nursing practice through the possible initiation of secondary and tertiary prevention strategies in cardiovascular disease.