PHYSICIAN SCIENTIST PROGRAM AWARD

中所述的物理学家-科学家奖计划的持续目标 这一更新申请将同时满足我们的需求， 在我们快速发展的Stein中担任领导职务的调查员 老龄化研究所，建立在大学校园内， 1983年，加州圣地亚哥大学。 身份证明， 招募和培训最聪明和最好的M。D.年代进入了 与衰老相关的临床研究的竞技场也将 符合国家老龄化研究所（NIA）的目标。 医生 在他们早年的临床培训将被邀请申请一个 为期五年的强化培训计划，将使他们具备强大的 真正富有成效的研究所需的基本科学方向， 生物医学问题。 本建议的重点是提供 使候选人能够对问题进行研究的轨道 与六个主要的身体系统有关， 在病理学的作用和发展中的作用。 第一 两到三年的培训将是最基本的， 希望受训人员能够利用前沿技术解决前沿问题， 方法. 在培训的这一阶段，候选人将 分配给在广泛的基础学科工作的教师赞助商 适用于生物医学问题。 直接实验室研究 经验将通过旨在填补的教学培训来补充 他们的基础科学背景的差距，以及弥补差距， 曾接受过与老年医学和老年医学相关的教育。 因此，在本发明中， 自由使用基础科学课程的丰富菜单 在拉霍亚校园提供，这将是一个补充 组织良好的老年医学/老年学课程。 最近两三 多年的培训将致力于研究问题的影响， NIA关注的六个集中领域之一的病理生理学。 加州大学圣地亚哥分校教师规划这个程序的核心是从 一般校园的生物和化学系，以及基础 以及医学院的临床教师。 他们每个人都被 选择的基础上，他们证明生产力的研究和他们的 在培训计划中的跟踪记录。 其中包括四名教师， 当选为国家科学院院士。 所有人都将拥有 我们的目标是培养这些年轻的研究人员， 几年后，他们将准备作为初级教师承担全部责任。 有自己的研究支持。 因为这是一个非凡的 该计划的成功和不断要求参与， 优秀的年轻临床医生，我们要求支持10 岗位

The continuing aims of the Physician-Scientist Award Program described in this renewal application will at the same time meet our needs for investigators in leadership positions for our rapidly-developing Stein Institute for Research on .Aging, established on the campus of the University of California San Diego in 1983. The identification, recruitment, and training of the brightest and best M. D.'s into the arena of clinical investigation on subjects related to aging will also meet the objectives of the National Institute on Aging (NIA). Physicians in their early years of clinical training will be invited to apply for a five-year intensive training program that will equip them with the strong basic science orientation needed for truly productive research on biomedical problems. Emphasis in this proposal is placed on providing tracks that will prepare candidates to carry out research on problems relating to some six major body systems that are prone to deterioration in function and development of pathology with advancing years. The first two or three years of training will be at the most basic level so that the trainees can, it is hoped, attack frontier problems using frontier methods. During this phase of their training, the candidates will be assigned to faculty sponsors working in fundamental disciplines of broad applicability to biomedical problems. Direct laboratory research experience will be supplemented by didactic training designed to fill gaps in their basic science background as well as to make up for gaps in previous education related to gerontology and geriatric medicine. Thus, liberal use will be made of the rich menu of basic science courses offered on the La Jolla campus and this will be supplemented by a well-organized course in geriatrics/gerontology. The last two or three years of training will be devoted to research problems bearing on the pathophysiology of one of the six concentration areas of interest to NIA. The nucleus of UCSD faculty planning for this program is drawn from the Departments of Biology and Chemistry on the general campus, and the basic and clinical faculty of the School of Medicine. They have each been selected on the basis of their proven productivity in research and their track records in training programs. Included are four faculty honored by election to the National Academy of Sciences. All will have as their goal the development of these young investigators so that after five years they will be ready for full responsibility as junior faculty members with their own research support. Because of the remarkable success of this program and continuing requests for participation by well-qualified young clinicians, we are requesting support for 10 positions.