BEHAVIOR, BIOLOGICAL RHYTHMS AND BRAIN

描述：P.I.建议继续并扩大他的研究， 昼夜视觉系统，即影响的神经解剖学基础 昼夜节律的光。 该提案有三个总目标： 第一个是了解作为调节剂的多巴胺能系统的作用， 昼夜节律的影响。 这一系列的研究将联合收割机 电刺激和药理学技术来评估（a） 由上行性肾上腺素能系统进行的昼夜节律时相控制，（B） 抑制性控制昼夜节律相位对光的反应， 上升的肾上腺素能系统和（c）阐明是否 中缝背核或正中核参与昼夜节律 调控 第二个是针对阐明的关系 在电子能系统和FOS蛋白的光电导之间， SCN或膝状体间小叶（IGL）细胞。 实验将 进行评估（a）血清素系统激活的能力 阻断SCN或IGL神经元中的FOS蛋白诱导，以及（B）是否 是中缝背核或中缝核， SCN和IGL中的活性。 第三组实验将研究 PLi -丘脑后界核是丘脑的“新”部分 昼夜视觉系统 这里的假设来自于观察 IGL在解剖学上与PLi相连，并继续 计划对IGL传出和传入解剖结构进行研究。 P.I. 将研究（a）IGL与PLi的关系，（B） 视网膜输入到PLi，（c）之间的传出/传入关系 IGL和上级丘，和（d）昼夜节律功能 的PLi。

DESCRIPTION: P.I. proposes to continue and extend his studies of the circadian visual system, i.e. neuroanatomical substrate of the effects of light of circadian rhythms. The proposal has three general aims: The first is to understand the role serotonergic system as a modulator of circadian rhythmicity. This series of studies will combine electrical stimulation and pharmacological techniques to evaluate (a) circadian phase control by the ascending serotonergic system, (b) inhibitory control of the circadian rhythms phase response to light by the ascending serotonergic system and (c) elucidation of whether the dorsal or median raphe nuclei are involved in circadian rhythm regulation. The second is directed towards the elucidation of the relationship between serotonergic system and the photoconduction of FOS-protein by SCN or intergeniculate leaflet (IGL) cells. Experiments will be conducted which evaluate (a) the ability of serotonin system activation to block FOS protein induction in SCN or IGL neurons and (b) whether it is the dorsal or median raphe nucleus that controls the serotonergic activity in the SCN and IGL. The third group of experiments will investigate the possibility that the PLi - the posterior limitans thalamic nucleus is a "new" part of the circadian visual system. The hypothesis here arises out of observations that the IGL is anatomical connected with the PLi, and continued investigations of IGL efferent and afferent anatomy are planned. P.I. will study (a) the IGL's relationship to the PLi, (b) the sites of retina input to the PLi, (c) the efferent/afferent relationship between the IGL and superior colliculus, and (d) the circadian rhythm function of the PLi.