PREFRONTAL CORTEX AND MEMORY PROCESSING

描述：（从抽象）本的主要目的 一项实验的目的是检验动物之间是否存在对应关系 和人类在前额叶皮层调节记忆功能方面的差异 并确定前额叶皮层的特定子区域 (e.g.,中央前内侧，前扣带，边缘下和边缘前， 背外侧额叶或外侧中央前，无颗粒岛状，和 腹内侧眶皮质）差异介导的特异性工作 不同属性的记忆功能，以及介导更高- 顺序关系基于信息的时间排序和配对 联想学习 先前对前额叶皮层大鼠的研究 损伤表明老鼠在工作记忆方面也有困难， 对于不同的属性，难以在时间上排序的具体 属性信息、学习困难和配对记忆保持 关联属性信息以及此外不同子 区域可以调节这些属性。 为了进一步阐述 前额叶皮层不同亚区在调节 工作记忆，Kesner博士开发了一套行为任务， 可以测量：a）不仅是空间位置的工作记忆， 由特定位置的对象定义，但也包括工作记忆 对于allocentric空间距离（2个对象之间的距离）， 自我中心的空间距离（主体和客体之间的距离） 以及独立于空间的视觉对象的工作记忆 位置，B）自我中心空间（运动，右-左）的工作记忆 转向反应）c）通过幅度测量的影响的工作记忆 d）用于顺序信息的记忆的滞后函数， 不仅用于空间位置的列表，而且用于视觉 对象，e）对象-对象、对象-空间的学习和表现 位置和空间位置-空间位置配对关联 信息. Kesner博士建议使用这种动物模型作为一种手段， 继续研究前额叶皮层在 中介工作记忆的具体属性信息和更高的- 顺序记忆过程，如时间顺序和配对联想 学习

DESCRIPTION: (From the abstract) The primary purpose of the present proposal is to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function and to determine whether specific sub-regions of the prefrontal cortex (e.g., medial precentral, anterior cingulate, infralimbic and prelimbic, dorsolateral frontal or lateral precentral, agranular insular, and ventromedial orbital cortex) differentially mediate specific working memory functions for different attributes as well as mediate higher- order relationships based on temporal ordering of information and paired associate learning. Previous research in rats with prefrontal cortex lesions has suggested that rats also have difficulty in working memory for different attributes, difficulty in temporal ordering of specific attribute information, difficulty in learning and retention of paired associate attribute information and furthermore that different sub- regions may mediate these attributes. In order to elaborate further on the role of different sub-regions of the prefrontal cortex in mediating working memory, Dr. Kesner has developed a set of behavioral tasks in which one can measure: a) not only working memory for spatial location, as defined by an object in a specific location, but also working memory for allocentric spatial distance (distance between 2 objects) and egocentric spatial distance (distance between subject and object) as well as working memory for visual objects independent of spatial location, b) working memory for an egocentric spatial (motor, right-left turn response) c) working memory for affect as measured by magnitude of reinforcement, d) a lag function for memory for order information not only for a list of spatial locations, but also for a list of visual objects, e) learning and performance of object- object, object-spatial location and spatial location-spatial location paired associate information. Dr. Kesner proposes to use this animal model as a means of continuing the investigation of the role of the prefrontal cortex in mediating working memory for specific attribute information and higher- order mnemonic processes such as temporal order and paired associate learning.