CCCWFU BREAST CANCER RESEARCH PROGRAM PLANNING GRANT

本申请的目的是提供资金，以建立一个 多学科广泛的基础设施，用于实施和继续 北京综合癌症研究中心乳腺癌研究进展 维克森林大学(CCCWFU)。CCCWFU是主要的第三级 皮埃蒙特地区转诊中心(五个州地区，包括 北卡罗来纳州西部)，并在癌症研究方面产生了重大计划 在这片区域。研究工作包括预防、筛查和 以临床试验为重点的治疗方案，包括 社区参与。此外，CCCWFU历史悠久， 对乳腺癌研究的兴趣体现在几个资助项目上 目前正在进行的项目。 此应用程序的目的是提供内部结构以组合 并扩大目前的研究努力，开发新的研究努力， 符合NCI指定的乳腺癌研究计划的标准。 我们当前计划的主要优势和我们计划的基础 计划包括：(1)抗氧化剂的评价和临床试验 预防药物；(2)社区和区域主要努力克服 老年乳腺癌预防、筛查和治疗的障碍 和少数族裔妇女；(3)确定新的预后因素 帮助预测早期乳腺癌患者的治疗反应 癌症；以及(4)有机会与我们的 与乳腺癌相关的信号转导亲和力强的群体。 我们建议的计划进一步增强：(1)临床医生的数量 对乳腺癌有主要研究兴趣的研究人员； 研究乳腺癌的实验室调查人员人数；其他 在癌症中心有能力和兴趣，但目前缺乏 拟议计划将提供的方向和重点；(3)不断增长的 具有专业知识和兴趣的流行病学家和社会科学家小组 在乳腺癌预防方面；(4)庞大、多样化的人口基数 临床和流行病学试验，由 维克森林大学综合癌症中心；(5)既往成功 具有跨学科的计划；以及(6)协作精神 机构、癌症中心和拟议项目之间的互动 会员。

The purpose of this application is to provide funding to establish a multidiscplinary broad based infrastructure for the conduct and continued development of breast cancer research at the Comprehensive Cancer Center of Wake Forest University (CCCWFU). The CCCWFU serves as the major tertiary referral center for the Piedmont region (a five state area including western North Carolina) and has generated major programs in cancer research in this area. Research efforts have included prevention, screening, and treatment programs with a major emphasis on clinical trials involving community participation. Moreover, the CCCWFU has had a long standing interest in breast cancer research as demonstrated by the several funded projects currently in progress. The purpose of this application is to provide the intrastructure to combine and expand current research efforts and develop new research efforts that satisfy the criteria for an NCI designated Breast Cancer Research Program. Major strengths of our current program and the foundation of our proposed program include: (1) evaluation and clinical trials of antioxidants as preventive agents; (2) major community and regional efforts to overcome barriers to prevention, screening and treatment of breast cancer in older and minority women; (3) the identification of new prognostic factors that help predict response to treatment in patients with early stage breast cancer; and (4) the opportunity to develop collaborative efforts with our strong signal transduction affinity group related to breast cancer. Our proposed program is further enhanced by: (1) the number of clinical investigators who have primary research interest in breast cancer; (2) the number of laboratory investigators who are studying breast cancer; others in the Cancer Center have the capability and interest but currently lack direction and focus that the proposed program will provide; (3) the growing group of epidemiologists and social scientists with expertise and interest in breast cancer prevention; (4) a large, diverse population base for clinical and epidemiologic trials which has been organized by the Comprehensive Cancer Center of Wake Forest University; (5) prior success with interdisciplinary programs; and (6) a spirit of collaborative interaction among institutional, Cancer Center and proposed program members.