IMPROVED CHARACTERIZATION OF DENTAL BIOMATERIALS

人们普遍认为，当前复合材料的服务性能 牙科中使用的树脂系统，如前牙和后牙 恢复剂，需要实质性的改进。为了做出所需的 我们必须更充分地了解是什么导致了复合材料的改进 现有系统的不足之处，需要改进 表征技术。此外，要充分评估新的 化学概念对于改进的复合材料来说也是非常重要的 已经改进了表征技术。作为一个例子，一个更好的 当分子水平上发生什么时，需要理解 复合体暴露在非常具有侵略性的口腔环境中 空洞。 有鉴于此，这一试点方案有一个新颖的两部分 推力。首先，该提案概述了关于发展 电子自旋共振(ESR)成像是一种非常强大的 在分子水平上观察扩散和变化的方法 复合材料。到目前为止还没有探索过的牙科复合材料的方法， 很有希望提供有关 牙科材料的特点。其次，我们建议证明 ESR成像是帮助指导合成的一个很好的工具， 改良用新化学的表征和发展 用于牙科和其他生物医学的高性能复合材料 申请。 在最初的工作中，模型(控制)树脂系统和目前 现有的可见光固化(VLC)复合材料将在37℃的水中老化 摄氏度为不同的时间段，水中含有可溶的 氮氧化物自旋探头。ESR成像将用于研究非均质， VLC材料的吸湿膨胀或膨胀特性。 测量扩散速度和/或过程和变化 分子水平，由于水的吸附，将是ESR研究的一个领域， 并与重量分析和核磁共振成像数据进行了比较。在… 同时，还将利用电子自旋共振技术对故障进行研究 商业和控制牙科生物材料的机理。模型 系统将被配制成比现有复合材料更疏水， 具有更强的抗蠕变能力、更高的抗压强度等，如 与基于双GMA的(控制)VLC系统相比。 在这项研究中开发的表征方法应该有助于确定 目前市场上最值得使用的材料是什么？ 如何修改它们以实现更高的性能。因此，实现 预期的目标应有助于将改进的牙科椅子 性能材料，有助于增强牙齿健康。

It is commonly accepted that the service performance of current composite resin systems used in dentistry, such as anterior and posterior restoratives, need substantial improvement. In order to make needed improvements in composites we must more fully understand what causes deficiencies in existing systems, which calls for improved characterization techniques. In addition, to adequately evaluate new chemical concepts for improved composites it is also very important to have improved characterization techniques. As an example, a better understanding is needed for what happens at the molecular level when composites are exposed to the very aggressive environment of the oral cavity. In consideration of the above, this pilot proposal has a novel two-part thrust. First, the proposal outlines studies for the development of electron spin resonance (ESR) imaging as an extraordinarily powerful method for observing diffusion and changes at the molecular level in composites. The method, heretofore unexplored for dental composites, holds great promise for giving new and significant information on the characteristics of dental materials. Secondly, we propose to demonstrate that ESR imaging is an excellent tool to help guide the synthesis, characterization, and development of new chemistry for improved performance composites used in dentistry and other biomedical applications. In the initial effort, model (control) resin systems and currently available visible light cured (VLC) composites will be aged in water at 37 degrees C for various time segments, with the water containing a soluble nitroxide spin probe. ESR imaging will be used to study non-homogeneous, hygroscopic expansion or swelling characteristics of the VLC materials. Measurement of diffusion rates and/or processes and changes at the molecular level, due to water sorption, will be one area of ESR study, with results compared with gravimetric analysis and NMR imaging data. At the same time, the ESR technique will be examined for study of the failure mechanisms of both commercial and control dental biomaterials. The model system will be formulated to be more hydrophobic than existing composites, have greater creep resistance, improved compressive strength, etc., as compared to BisGMA based (control) VLC systems. Characterization methods developed in this study should help ascertain what materials currently in the market place are most worthy of use and how they may be modified to achieve improved performance. Thus, achieving the intended goals should facilitate bringing to the dental chair improved performance materials, contributing to enhanced dental health.