HOST TUMOR INTERACTION IN BURKITTS LYMPHOMA

SJL小鼠滤泡中心B细胞模型的研究进展 淋巴瘤（RCS）已经建立了一个强有力的联系之间的转录， 一种新的内源性小鼠乳腺肿瘤病毒（MMTV）， 间接癌基因，介导强烈的超抗原样刺激， RCS生长所依赖的同基因CD 4 + V β 16 + T细胞。 RCS淋巴瘤与伯基特淋巴瘤有许多共同的显著特征 （BL）。 两种淋巴瘤都是生发中心来源的（都表达 生殖细胞中心特异性抗原，CD 77）;和类似RCS淋巴瘤，BL肿瘤 有T细胞浸润，这可能在 淋巴瘤形成 本提案的总体目标是利用 RCS模型中的发现作为解剖宿主T 细胞在BL的发育过程中。 鉴于BL的异质性， 肿瘤，我们将研究一些非洲BL肿瘤从各种 加纳（BL流行）的患者，试图将肿瘤 表型与其刺激特定宿主T细胞亚群有关 以及它们对凋亡的敏感性。

Our recent work on the SJL mouse model of follicular center B cell lymphoma (RCS) has established a strong link between the transcription of a novel endogenous mouse mammary tumor virus (MMTV) that serves as an indirect oncogen, mediating the vigorous superantigen-like stimulation of syngeneic CD4+Vbeta16+ T cells upon which RCS depend for their growth. RCS lymphomas share a number of salient features with Burkitt's lymphomas (BL). Both lymphomas are germinal center derived (both express the germinal center specific antigen, CD77); and like RCS lymphomas, BL tumors have T cell infiltrations that could have a potential role in the lymphomagenesis. The overall aim of this proposal is to utilize the findings in the RCS model as a basis for dissection of the role of host T cells in the development of BL. In view of the heterogeneous nature of BL tumors, we will examine a number of African BL tumors from various patients in Ghana (where BL is prevalent) in an attempt to relate tumor phenotypes to their stimulation of particular host T cell subpopulations and to their sensitivity to apoptosis.