CONFERENCE ON MOLECULAR BIOLOGY OF MUSCLE DEVELOPMENT

部分支持请求的基石研讨会，“分子生物学 肌肉发展”，将在雪鸟会议中心举行， 雪鸟犹他州，1994年4月11日至17日。 这是第三次Keystone研讨会 在骨骼肌生物学，并将重点放在最近的进展， 成为研究基础的最活跃的研究领域之一 细胞决定的机制，以及细胞之间的关系， 增殖和分化。 骨骼肌成肌细胞来源于 中胚层干细胞，成为致力于肌细胞谱系。 骨骼肌分化与成肌细胞从骨骼肌中退出有关。 细胞周期，并伴随着结构的转录激活 和调节基因。 许多肌肉特异性的控制区域 基因已经被定义并显示与细胞类型特异性相互作用， 以及广泛表达的转录因子。 这其中包括 螺旋-环-螺旋蛋白的MyoD家族的成员，其可以激活 在各种非肌肉细胞类型中的肌生成。 这些和其他最近 发现的因素在一个调节网络中起作用， 肌肉细胞的分化和生长。 新型转基因动物模型 促进了肌肉细胞培养中获得的知识的应用 系统来了解体内肌肉发育。 了基础 在阐明分子生物学中， 胚胎骨骼肌特化的机制 前体，肌纤维多样性的产生， 在发育和老化的肌肉中的成肌细胞增殖和分化， 以及神经肌肉疾病的基因解剖 这次会议是 旨在汇集具有广泛兴趣的研究人员， 专业知识，提供全面和多学科的观点， 快速移动的领域 该计划将整合最近取得进展的领域 在骨骼肌的分子生物学中，特别强调 发展机制。 会议将分为十次全体会议 会议（口头介绍），三个讲习班，重点是最近 在当前高度关注的更专业的主题方面取得进展， 允许参与者之间进行讨论和科学交流， 海报展示会，有充足的时间进行非正式意见交流， 想法. 大约350名国内外科学家将在 出席;与会者将根据质量选择 他们的工作以及这将如何加强会议。 G 与会者将代表从研究生到 资深调查员 这次会议的总体目标是让一个 综合了肌肉发育生物学不同领域的观点， 和制定新的概念，为未来的研究方向， 该领域

Partial support is requested to the Keystone Symposium, "Molecular Biology of Muscle Development", to be held at the Snowbird Conference Center, Snowbird Utah from April 11-17, 1994. This is the third Keystone symposium on skeletal muscle biology and will focus on recent advances in what has become one of the most active areas of research for studying basic mechanisms of cell determination, as well as the relationship between cell proliferation and differentiation. Skeletal myoblasts arise from mesodermal stem cells that become committed to the myogenic lineage. Skeletal differentiation is linked to the withdrawal of myoblasts form the cell cycle and is accompanied by transcriptional activation of structural and regulatory genes. The control regions of numerous muscle-specific genes have been defined and shown to interact with cell-type specific as well as widely expressed transcription factors. Among these are the members of the MyoD family of helix-loop-helix proteins, which can activate myogenesis in a variety of non-muscle cell types. These and other recently discovered factors function within a regulatory network that influences muscle cell differentiation and growth. Novel transgenic animal models have facilitated the application of knowledge gained in muscle cell culture systems to an understanding of muscle development in vivo. The groundwork has been laid for unprecented advances in elucidating the molecular mechanisms underlying the specification of embryonic skeletal muscle precursors, the generation of muscle fiber diversity, the control of myoblast proliferation and differentiation in developing and aging muscle, and the genetic dissection of neuromuscular disorders. The meeting is intended to bring together researchers with a broad range of interests and expertise to provide a comprehensive and multidisciplinary view of this rapidly moving field. The program will integrate areas of recent progress in the molecular biology of skeletal muscle, with special emphasis on mechanisms of development. The meeting will be organized into ten plenary sessions (for oral presentation), three workshops focusing on recent advances in more specialized topics of high current interest which will allow discussion and scientific exchange between participants, and four poster sessions, with ample time for informal exchange of observations and ideas. Approximately 350 foreign and domestic scientists will be in attendance; the participants will be selected on the basis of the quality of their work and how it will enhance the meeting. g Conferees will represent all levels of scientists from graduate student to senior investigators. The overall goal of this meeting is to allow a synthesis of ideas from different areas of muscle developmental biology, and the formulation of new concepts for future directions of research in this field.